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| 丁香降气颗粒的提取工艺研究 | |
| 引用本文： | 张丽红,付艳,张志荣,王建新,马淑颖,朱生樑. 丁香降气颗粒的提取工艺研究[J]. 中国中药杂志, 2007, 32(21): 2252-2255 |
| 作者姓名： | 张丽红 付艳 张志荣 王建新 马淑颖 朱生樑 |
| 作者单位： | 1. 复旦大学,药学院,药剂学教研室,上海,200032;四川大学,华西药学院,药剂教研室,四川,成都,610041 2. 四川大学,华西药学院,药剂教研室,四川,成都,610041 3. 复旦大学,药学院,药剂学教研室,上海,200032 4. 上海中医药大学,附属岳阳中西医结合医院,上海,200437 |
| 摘 要： | 目的：筛选并优化丁香降气颗粒的提取工艺。方法：通过药效学实验比较和确定提取工艺路线,正交设计多指标优化提取工艺条件。结果：水提法工艺提取物改善大鼠食管炎症的疗效优于其他3种工艺提取物；通过正交试验优化确定的提取条件为：加水提取3次,每次12倍量水,提取0.5 h。结论：优化得到的提取工艺合理、稳定、可行,保证了原处方的疗效。 |
| 关 键 词： | 丁香降气颗粒 提取工艺 药效学评价 正交设计 |
| 文章编号： | 1001-5302（2007）21-2252-04 |
| 收稿时间： | 2007-01-10 |
| 修稿时间： | 2007-01-10 |
Optimal extraction of Dingxiang Jiangqi granules |
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| ZHANG Li-hong; FU Yan; ZHANG Zhi-rong; WANG Jian-xin; MA Shu-ying; ZHU Sheng-liang. Optimal extraction of Dingxiang Jiangqi granules[J]. China Journal of Chinese Materia Medica, 2007, 32(21): 2252-2255 | |
| Authors: | ZHANG Li-hong FU Yan ZHANG Zhi-rong WANG Jian-xin MA Shu-ying ZHU Sheng-liang |
| Affiliation: | Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China. |
| Abstract: | Objective: To screen and optimize the extraction of Dingxiangjiangqi granules.Method: The extraction route was screened by using pharmacodynamic experiment and the extraction conditions were optimized by orthogonal design and taking extract yield,content of naringin and tetrahydropalmatine as indexes.Result: The pharmacodynamic result showed that aqueous extract had the best effect to cure the esophagitis of rats and the optimized extraction technique was adding 12 times water,extracting 0.5 hour for 3 times.Conclusion: The optimum extraction was simple,reasonable,stable and useful for further development. |
| Keywords: | Dingxiangjiangqi granules extraction pharmacodynamic evaluation orthogonal design |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |