| 微小RNA在白血病中的作用及治疗策略 |
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| 引用本文： | 谷景义,朱雪娇,李育敏,费嘉.微小RNA在白血病中的作用及治疗策略[J].国外医学(药学分册),2011(1):28-32,57. |
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| 作者姓名： | 谷景义 朱雪娇 李育敏 费嘉 |
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| 作者单位： | 暨南大学医学院生物化学教研室; |
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| 基金项目： | 暨南大学科研培育与创新基金前瞻性与基础研究项目(11609406);暨南大学研究生精品课程(医学分子生物学)建设项目(50623021) |
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| 摘 要： | 微小RNA（microRNA,miRNA）是一类由19～25个核苷酸组成的非编码蛋白质的单链小分子RNA,其在白血病中扮演着癌基因和抑癌基因的角色,针对miRNA在白血病中的不同作用,可采取相应的治疗策略。对于在白血病中高表达的具有癌基因功能的miRNA,可采用反义寡核苷酸等技术下调或抑制miRNA;而对于在白血病中显著低表达、发挥着抑癌基因作用的miRNA,可采用基因治疗的方法,导入相应的外源miRNA,使其正常表达。因此,miRNA对于白血病的基因治疗或作为白血病治疗的新靶标具有广阔的应用前景。
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| 关 键 词： | 微小RNA 癌基因 抑癌基因 反义寡核苷酸 白血病 |
Role and treatment strategies of microRNA in leukemia |
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| GU Jing-yi,ZHU Xue-jiao,LI Yu-min,FEI Jia.Role and treatment strategies of microRNA in leukemia[J].Foreign Medical Sciences(Section of Pharmarcy),2011(1):28-32,57. |
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| Authors: | GU Jing-yi ZHU Xue-jiao LI Yu-min FEI Jia |
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| Institution: | GU Jing-yi,ZHU Xue-jiao,LI Yu-min,FEI Jia(Department of Biochemistry,Medical College of Jinan University,Guangzhou 510632,China) |
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| Abstract: | MiroRNA(miRNA) is a class of non-coding single-chain RNA comprising of 19-25 nucleotides,as oncogenes and tumor suppressor genes in leukemia.The appropriate treatment strategies can be taken according to their different roles.As oncogenes highly expressed in leukemia,miRNA can be reduced or inhibited by technologies such as antisense oligonucleotides;when miRNA expressed lower in leukemia as tumor suppressor genes,gene therapy methods can be taken to introduce corresponding exogenous miRNA to cells to norma... |
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| Keywords: | microRNA oncogenes tumor suppressor genes antisense oligonucleotide leukemia |
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