| 长期联合化疗对成人白血病患者外周血细胞姐妹染色单体交换率的影响 |
| |
| 引用本文： | 梁英民,蒋姗姗,吴绒丽,杜娟,陈任安,刘强,郑谨. 长期联合化疗对成人白血病患者外周血细胞姐妹染色单体交换率的影响[J]. 白血病．淋巴瘤, 2001, 10(3): 136-137 |
| |
| 作者姓名： | 梁英民 蒋姗姗 吴绒丽 杜娟 陈任安 刘强 郑谨 |
| |
| 作者单位： | 第四军医大学唐都医院,陕西,西安,710038 |
| |
| 摘 要： | 目的 :探讨长期联合化疗对缓解期成人白血病患者是否有潜在的诱变性。方法 :应用姐妹染色单体交换 (SCE)技术检测 44例白血病患者外周血细胞 SCE率的改变。结果 :初治、复发的急性白血病 (AL)和 CML组患者 SCE频率明显高于 CR- AL 组和正常对照组 ;CR- AL 仍有少部分高 SCE病例 (5 / 16 ) ,而此类病例主要分布在接受联合化疗在 9个疗程以上的 CR- AL 的患者中 (3/ 6 )。结论 :初治、复发 AL 和 CML 患者存在着 DNA的损伤或 DNA修复机制缺陷 ,长期反复联合化疗可能引起部分病例 DNA的不稳定。
|
| 关 键 词： | 姐妹染色单体交换 化疗 白血病 |
| 文章编号： | 1006-6934(2001)03-0136-02 |
| 修稿时间： | 2000-07-17 |
EFFECTS OF LONG-TERM COMBINED CHEMOTHERAPY ON SISTER CHROMATID EXCHANGE IN THE PATIENTS WITH ADULT LEUKEMIA |
| |
| LIANG Ying min,JIANG Shan shan,WU Rong li,et al.. EFFECTS OF LONG-TERM COMBINED CHEMOTHERAPY ON SISTER CHROMATID EXCHANGE IN THE PATIENTS WITH ADULT LEUKEMIA[J]. Journal of Leukemia & Lymphoma, 2001, 10(3): 136-137 |
| |
| Authors: | LIANG Ying min JIANG Shan shan WU Rong li et al. |
| |
| Affiliation: | LIANG Ying min,JIANG Shan shan,WU Rong li,et al. Tang Du Hospital of Fourth Military Medical University |
| |
| Abstract: | Objective:To explore the possibility of secondary neoplasia following long term combined chemotherapy.Methods:Sister chromatid exchanges(SCE)were investigated in 44 patients with adult leukemia.Rusults:Frequencies of SCE in patients with de novo leukemia,relapsed leukemia and chronic myeloid leukemia(CML)were significant higher than health controls.The five patients(5/16)with complete remission showed higher SCE frequencies,those were mainly the patients received more than nine courses of combined chemotherapeutic regimens received more than nine courses of combined chemotherapeutic regimens.Conclusion:The patients with de novo leukemia,relapsed leukemia and CML have DNA damage in diagnosis,long term combined chemotherapy may cause the DNA instability in partial patients. |
| |
| Keywords: | Sister chromatid exchange Chemotherapy Adult leukemia |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
