口腔颌面外科围术期预防性应用抗菌药物干预对照研究

目的:评价我院口腔颌面外科实施干预措施对围术期应用抗菌药物的效果。方法:选取我院口腔颌面外科实施干预措施前(2008年6-12月,干预前)、后(2010年6月-2011年6月,干预后)出院患者的病历各370份进行对照研究,对围术期抗菌药物的预防性应用情况进行回顾性分析。结果:较之干预前,干预后Ⅰ、Ⅱ类切口围术期预防性应用抗菌药物的合理性明显提高,术前用药时机合理率达67.6%,术后平均用药时间由干预前的5.13d缩短至3.48d,干预前存在的主要不合理用药现象得到抑制。结论:我院采取的抗菌药物预防性应用干预措施明显提高了合理用药水平,体现了干预措施的有效性和可行性。对存在的抗菌药物应用比例偏高、疗程较长等问题,需继续加强督导和监控。

Control Study of Intervention Measures for Perioperative Prophylactic Application of Antibiotics in Decorative Surgery Department

OBJECTIVE：To evaluate the effect of intervention measures for perioperative prophylactic application of antibiotics in decorative surgery department of our hospital.METHODS：Medical records of 370 surgery patients in our hospital were collected and studied comparatively before（Jun.-Dec.2008）and after carrying out intervention measures（Jun.2010-Jun.2011）.The perioperative prophylactic application of antibiotics was analyzed retrospectively.RESULTS：The rationality of perioperative prophylactic application of antibiotics in typeⅠandⅡincision was markedly improved.Reasonable rate of medication timing before operation was 67.6%;the mean medication time were shorted from 5.13 d to 3.48 d;some major problems were improved significantly after intervention.CONCLUSION：The intervention measures advocated by our hospital promote the level of rational drug use and represent the feasibility and effectiveness of intervention measures.To high proportion of antibiotics use and long period of treatment,we need to strengthen the supervision of clinical pharmacy personnel and monitoring.