喜炎平注射液治疗小儿轮状病毒肠炎合并心肌损害的疗效观察

目的:观察喜炎平注射液治疗小儿轮状病毒肠炎合并心肌损害的临床疗效。方法:将80例患者随机均分为对照组和观察组,观察组给予喜炎平注射液(5mg·kg-1d-1)并对症补液治疗;对照组给予利巴韦林注射液(10～15mg·kg-1·d-1)并对症补液治疗。2组病例均在初治和治疗5～7d后检查和复查心肌酶谱水平。结果:治疗后2组心肌酶谱水平均较治疗前有显著下降(P<0.05);组间比较除乳酸脱氢酶外,均有显著性差异(P<0.05);观察组总有效率为95%,对照组为77.5%,2组比较有显著性差异(P<0.05)。结论:喜炎平注射液治疗小儿轮状病毒肠炎合并心肌损害有明显疗效,且未见明显不良反应。

Efficacy Observation of Xiyanping Injection in the Treatment of Infantile Rotavirus Enteritis Complicating with Cardiac Damage

OBJECTIVE： To observe the clinical efficacy of Xiyanping injection in the treatment of infantile rotavirus enteritis complicating with cardiac damage. METHODS： 80 children were randomly divided into control group and observation group （40 cases in each group）. The patients in observation group were given Xiyanping injection （5 mg·kg·d-1） and symptomatic treatment, and the patients in control group were given Virazole injection（10- 15 mg·kg·d-1） and symptomatic treatment. The cards cardiac enzymes spectrum of 2 groups were checked and rechecked at the beginning of treatment and 5-7 days after treatment. RESULTS： The cards cardiac enzymes spectrum of 2 groups decreased significantly after treatment, compared with before treatment（P〈0.05）. There were significant difference between 2 groups, besides LDH （P〈0.05）. The total effective rate in the observation group was 95%, while in control group was 77.5%, There was significant difference between the two groups （P〈0.05）. CONCLUSION： Xi- yanping injection is significantly effective for infantile rotavirus enteritis complicating with cardiac damage without obvious adverse drug reactions. KEY WORDS Xiyanping injection; Rotavirus enteritis; Cardiac damage