| 京尼平苷对谷氨酸钠诱导性肥胖小鼠的减肥作用研究 |
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| 引用本文： | 石磊,孙静,李玲,张婷婷,阳光,宋光明. 京尼平苷对谷氨酸钠诱导性肥胖小鼠的减肥作用研究[J]. 中国药房, 2011, 0(39): 3671-3673 |
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| 作者姓名： | 石磊 孙静 李玲 张婷婷 阳光 宋光明 |
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| 作者单位： | [1]武警医学院附属医院药剂科,天津市300162 [2]武警医学院药理教研室,天津市300162 |
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| 摘 要： | 目的:研究京尼平苷对L-谷氨酸钠(MSG)诱导性肥胖小鼠的减肥作用。方法:观察京尼平苷对MSG肥胖小鼠体重、Lee氏指数、血糖、血甘油三酯、血胆固醇、脂肪细胞大小的影响。结果:800mg·kg-1剂量下京尼平苷可明显抑制MSG肥胖小鼠的摄食量,减轻体重,降低血甘油三酯、血胆固醇含量,使白色脂肪细胞变小,但对血糖无影响。结论:京尼平苷对MSG肥胖小鼠具有减肥作用。
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| 关 键 词： | 京尼平苷 L-谷氨酸钠诱导性肥胖小鼠 体重 血脂 脂肪细胞 |
Antiobesity Effects of Geniposide on Monosodium Glutamate-induced Obese Mice |
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| SHI Lei,SUN Jing,LI Ling,ZHANG Ting-ting,YANG Guang,SONG Guang-ming. Antiobesity Effects of Geniposide on Monosodium Glutamate-induced Obese Mice[J]. China Pharmacy, 2011, 0(39): 3671-3673 |
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| Authors: | SHI Lei SUN Jing LI Ling ZHANG Ting-ting YANG Guang SONG Guang-ming |
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| Affiliation: | 1 Dept. of Pharmacy, The Affiliated Hospital of Medical College of Chinese People＇ s Armed Police Force, Tianjin 300162, China;2Dept. of Pharmacology, Medical College of Chinese People＇ s Armed Police Force, Tianjin 300162, China) |
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| Abstract: | OBJECTIVE： To study the antiobesity effects of geniposide on L-monosodiurn glutamate （MSG）induced obese mice. METHODS： The effects of geniposideon on body weight, Lee index, blood glucose, triglycerides, blood cholesterol and adipocyte size were observed in MSG-induced obese mice. RESULTS： Geniposide （800 mg·kg^-1） could inhibit food intake of MSG-induced obese mice, reduce the body weight and the level of triglscorides, blood cholesterol. White fat cell became smaller but it had no effect on blood glucose. CONCLUSIONS： Geniposide have antiobesity effects on MSG-induced obese mice. |
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| Keywords: | Geniposide MSG-induced obese mice Body weight Blood lipids Adipocyte |
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