临床药师参与胸腔恶性孤立性纤维性肿瘤化疗1例并文献复习

目的:探讨恶性孤立性纤维性肿瘤的化疗方案,促进合理用药。方法:报道临床药师参与1例胸腔恶性孤立性纤维性肿瘤患者治疗过程,观察手术治疗后用多西他赛和奈达铂联合化疗效果并查阅相关文献。结果:患者化疗3个疗程后复查CT显示肿瘤复发并胸壁转移。文献报道对孤立性纤维性肿瘤有效的化疗方案有索拉非尼+阿霉素联用、丝裂霉素C+多西他赛联用、贝伐单抗+替莫唑胺联用、单用伊马替尼等。结论:该患者经过多西他赛和奈达铂联合对胸腔恶性孤立性纤维性肿瘤化疗后,稳定期为3个月。

A Case of Clinical Pharmacist Participating in Chemotherapy Regimens for Intrapleural Malignant Solitary Fibrous Tumor and Literature Review

OBJECTIVE： To investigate chemotherapy regimens for malignant solitary fibrous tumor and promote rational drug use. METHODS： A case of clinical pharmacist participating in the treatment of intrapleural malignant solitary fibrous tumor was reported. Efficacy of combination therapy of docetaxel and nedaplatin after surgical treatment was observed and related literature was reviewed. RESULTS： After 3 courses of chemotherapy, solitary fibrous tumor recurred and transferred to chest wall on CT scans. Effective chemotherapy regimens of solitary fibrous tumor through literature review included combination therapy of sorafenib with adriamycin,mitomycin C with docetaxel, bevacizumab with temozolomide, and imatinib alone and so on. CONCLUSION： After the patient receives combination therapy of docetaxel with nedaplatin, tumor stable period is 3 months.