| 土茯苓水提物对高尿酸血症模型小鼠血清尿酸和甘油三酯、胆固醇的影响 |
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| 引用本文： | 郭淑云,张薇,张琰,杜小燕. 土茯苓水提物对高尿酸血症模型小鼠血清尿酸和甘油三酯、胆固醇的影响[J]. 中国药房, 2011, 0(47): 4439-4440 |
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| 作者姓名： | 郭淑云 张薇 张琰 杜小燕 |
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| 作者单位： | [1]第四军医大学第二附属医院药剂科,西安市710038 [2]第四军医大学第二附属医院儿科,西安市710038 |
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| 摘 要： | 目的:研究土茯苓水提物对高尿酸血症模型小鼠血清尿酸(UA)和甘油三酯(TG)、胆固醇的影响。方法:实验分为空白(等容蒸馏水)、模型(等容蒸馏水)、土茯苓水提物(10g(生药)·kg-1)、别嘌呤醇(40mg·kg-1)组。ig酵母30g·kg-11周复制模型,复制模型成功后分别ig相应药物,7d后检测各组大鼠血中胆固醇、TG、UA含量和黄嘌呤氧化酶(XOD)活性。结果:与模型组比较,土茯苓组小鼠血清UA、TG、胆固醇含量和XOD显著降低(P>0.05或P<0.01)。结论:土茯苓对高尿酸血症模型小鼠肾功能有保护作用,对UA升高有明显的抑制作用。
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| 关 键 词： | 土茯苓 高尿酸血症 甘油三酯 黄嘌呤氧化酶 |
Effect of Smilax glabra Water-extracts on Serum Uric Acid, Triglyceride and Cholesterol in Hyperuricemia Rats |
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| GUO Shu-yun,ZHANG Yan,DU Xiao-yan. Effect of Smilax glabra Water-extracts on Serum Uric Acid, Triglyceride and Cholesterol in Hyperuricemia Rats[J]. China Pharmacy, 2011, 0(47): 4439-4440 |
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| Authors: | GUO Shu-yun ZHANG Yan DU Xiao-yan |
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| Affiliation: | (Dept. of Pharmacy, The Second Affiliated Hospital of Forth Mili- tary Medical University, Xi＇an 710038, China) ZHANG Wei (Dept. of Pediatrics, The Second Affiliated Hospital of Forth Military Medical University, Xi＇ an 710038, China) |
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| Abstract: | OBJECTIVE： To observe the effect of Smilax glabra water-extracts on the serum uric acid, triglyceride （TG） and cholesterol in rats with hyperuricemia. METHODS： Rats were divided into blank group （same volume of distilled water）, model group （same volume of distilled water）, S. glabra water-extracts group （10 g（crude）, kg-1） and allopurinol group （40 mg. kg-J）. Hy- peruricemia model was induced by intragastrieal administration of yeast 30 g. kg-1for a week. After successfully building the mod- els, rats were given drug respectively. 7 days later, the content of cholesterol, TG, UA and the activity of XOD of the rats in dif- ferent groups were all determined. RESULTS： Compared with model group, the content of UA, TG, cholesterol and the activity of XOD in S. glabra water-extracts group decreased remarkably（P〈0.05 or P〈0.01）. CONCLUSION： S. glabra water-extracts has protective effect on the kidney function of rat with hyperuricemia and it also has therapeutic effect on elevation of uric acid. |
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| Keywords: | Smilax glabra Hyperuricemia Triglyceride XOD |
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