阿昔洛韦与更昔洛韦治疗成人水痘的疗效比较

目的:比较阿昔洛韦与更昔洛韦治疗成人水痘的疗效。方法:将我院140例水痘患者,按住院单双日随机均分为阿昔洛韦组与更昔洛韦组,分别给予阿昔洛韦与更昔洛韦10mg.kg-1,bid,静脉滴注。观察并记录2组患者的退热时间、皮疹结痂时间、总有效率和不良反应。结果:更昔洛韦组患者的退热时间明显短于阿昔洛韦组,2组比较差异有统计学意义(P<0.05);2组的皮疹结痂时间比较,差异无统计学意义(P>0.05);更昔洛韦组的总有效率明显高于阿昔洛韦组(P<0.05)。2组治疗过程中,均未见不良反应发生。结论:更昔洛韦治疗成人水痘的疗效显著优于阿昔洛韦,且退热时间短于阿昔洛韦。

Comparison of Therapeutic Efficacy of Acyclovir and Ganciclovir in the Treatment of Adult Chickenpox

To compare the therapeutic efficacy of acyclovir vs. ganciclovir in the treatment of adult chickenpox. METHODS： 140 patients with chickenpox in our hospital were randomly divided into acyclovir group and ganciclovir group, ac- cording to odd and even days of hospitalization. They were given acyclovir and ganciclovir 10 mg.kg ~, bid, iv.gtt. The average de- fervescence time, the time for herpes forming a scab, total effective rate and adverse drug reaction were observed in 2 groups. RE- SULTS： The defervescence time of ganciclovir group was significantly shorter in acyelovir group, the difference was statistically significant （P〈0.05） ; The time for herpes forming a scab had no statistical significance in the difference between 2 groups （P〈0.05） ; Total effective rte of ganciclovir group was significantly higher than that of acyclovir group, the difference was statistically significant （P〈O.05）. No adverse drug reaction was found in 2 groups during the treatment. CONCLUSIONS： The therapeutic effi- cacy of ganciclovir in the treatment of adult varicella is significantly better than acyclovir, and the defervescence time of ganciclo- vir is shorter than acyclovir.