乌灵胶囊和黛力新治疗广泛性焦虑症对照研究

目的观察乌灵胶囊对广泛性焦虑症的疗效与安全性。方法采用平行对照研究方法，治疗组30例患者给予口服乌灵胶囊3粒，3次／日；对照组30例患者给予口服黛力新1片，2次／日。于治疗前及治疗后第1周、2周、4周、6周分别以汉密顿焦虑量表（Hamilton Anxiety Scale，HAMA）、汉密顿抑郁量表（Hamilton Depression Scale，HAMD）、治疗时出现的症状量表（Treatment Emergent Symptoms．TESS）及实验室检查评估疗效与安全性。结果治疗组、对照组总有效率分别为73％、77％，二组之间疗效无显著差异。治疗组未见明显不良反应，对照组不良反应发生率为11％，主要为口干、过度镇静和头痛。结论乌灵胶囊是治疗广泛性焦虑症疗效可靠、安全的药物。

A paralleled compared study of Wuling capsule and Deanxit in the treatment of general anxiety disorder

Objective: To evaluate the efficacy and side effects of Wuling capsule compared with Deanxit in the treatment of general anxiety disorder(GAD). Methods: 60 patients met Chinese classification and diagnostic criteria of mental disorders, 3nd Rev Ed, criteria for GAD were assigned to Wuling capsule group (therapy group,n=30) and Deanxit group (controlled group,n= 30) for 6 weeks. Efficacy and side effects were evaluated with Hamilton Anxiety Scale (HAMA ) , Hamilton Depression Scale(HAMD) and Treatment Emergent Symptoms Scale(TESS) before treatment and 1,2,4,6 weeks after treatment. Results:There was no significant difference in response rate between the two groups(Wuling group:73%,Deanxit group:77%). There was no significant side effects of Wuling group.The incidence of side effects of Deanxit group was 11% .The main side effects were dry mouth, sedation and headache.Conclusion:Wuing capsule was effective and safe in the treatment of GAD .