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Survivin在非霍奇金淋巴瘤中的表达及意义
引用本文:刘新,李颖,徐功立,许洪志. Survivin在非霍奇金淋巴瘤中的表达及意义[J]. 山东大学学报(医学版), 2007, 45(3): 283-285
作者姓名:刘新  李颖  徐功立  许洪志
作者单位:山东大学医学院山东省立医院血液科,山东,济南,250021;山东大学医学院山东省立医院血液科,山东,济南,250021;山东大学医学院山东省立医院血液科,山东,济南,250021;山东大学医学院山东省立医院血液科,山东,济南,250021
摘    要:目的:探讨Survivin抗原在非霍奇金淋巴瘤(NHL)中的表达及临床意义。方法: 采用免疫组织化学SP方法,检测Survivin在52例NHL及12例淋巴结反应性增生(RH)中的表达情况。结果:Survivin在淋巴结反应性增生中的阳性表达率明显低于NHL,侵袭性NHL表达水平明显高于惰性NHL。Survivin在非霍奇金淋巴瘤的表达与性别、年龄、患者临床分期、有无全身症状、患者淋巴瘤细胞来源、首发部位无关。LDH<250U/L NHL Survivin 阳性表达率明显低于LDH>250 U/L NHL Survivin阳性表达率。Survivin 阳性表达率>25%非霍奇金淋巴瘤患者与阳性表达率<25%非霍奇金淋巴瘤患者相比较,平均生存期短。结论:Survivin与NHL的发生发展有关,并可对预后判断提供参考依据。

关 键 词:免疫组织化学  淋巴瘤  非霍奇金  Survivin
文章编号:1671-7554(2007)03-0283-03
收稿时间:2006-07-03
修稿时间:2006-07-03

Significance and expression of Survivin protein in non-Hodgkin's lymphoma
LIU Xin,LI Ying,XU Gong-li,XU Hong-zhi. Significance and expression of Survivin protein in non-Hodgkin's lymphoma[J]. Journal of Shandong University:Health Sciences, 2007, 45(3): 283-285
Authors:LIU Xin  LI Ying  XU Gong-li  XU Hong-zhi
Affiliation:Department of Hematology, Shandong Provincial Hospital, School of Medicine, Shandong University, Jinan 250021, Shandong, China
Abstract:Objective: To explore the expression of Survivin in non-Hodgkin′s lymphoma cells with variable aggressiveness and its clinical significance. Methods: The SP immunohistochemistry staining method was used to detect the expression of Survivin. Results: The positive rate of Survivin in the reactive hyperplasia of the lymph node was lower than that in non-Hodgkin′s lymphoma. The positive rate of Survivin was related to the aggressiveness of non-Hodgkin′s lymphoma, but it was not related to the sex, age, clinical stage, body symptoms, immunotype and initial organ. Different Survivin expressions were found between different levels of LDH. High Survivin expression was associated with low survival stage. Conclusion: Survivin may play certain roles in the oncogenesis and the progression of non-Hodgkin s lymphoma, and it has positive effects on the prognosis of non-Hodgkin s lymphoma.
Keywords:Survivin
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