Male specific association between the 5-HTR6 gene 267C/T SNP and suicide in the Portuguese population |
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Authors: | Diana Azenha Mariana Alves Rita Matos Jerónimo Fonte Santa Beatriz Silva Cristina Cordeiro Duarte Nuno Vieira Alda M Ambrósio |
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Institution: | 1. Clinical and Molecular Genetics Unit, National Institute of Legal Medicine, Coimbra, Portugal;2. National Institute of Legal Medicine, Coimbra, Portugal;3. Faculty of Medicine, University of Coimbra, Coimbra, Portugal |
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Abstract: | Serotonergic system dysfunction has been implicated in the etiology of suicide. A large number of genetic studies have focused on the potential involvement of genes coding for components of serotonergic system in suicidal behavior. However, other genes belonging to this system remain to be investigated or have been poorly studied, as is the case of the 5-HT6 receptor (5-HTR6) gene. In this study, we investigated the potential association between the 5-HTR6 gene 267C/T SNP and suicide in a Portuguese population. Blood samples were collected from 179 suicide victims and 189 controls. Genotypes for the 5-HTR6 gene 267C/T SNP were obtained with the restriction enzyme Rsa I. A tendency was found for genotype association between this polymorphism and suicide, but the differences were not statistically significant (χ2 = 5.374, df = 2, p = 0.068). However, a gender-specific association was detected when comparing the genotype distribution between male suicide victims and male controls (χ2 = 6.988, df = 2, p = 0.030), suggesting that this SNP might have a role in the etiology of suicide in male subjects in the Portuguese population. |
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Keywords: | Genetics Male suicide victims 5-HTR6 gene 267C/T SNP |
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