| Abstract: | It is shown that alcoholization of rats during 1.5 months by the inhalation of ethanol vapors with a long-term subsidence
into narcotic sleep results in alcohol dependence and marked shifts in the ratio between the activity of malate and lactate
dehydrogenases and a change in the isoenzyme spectrum of the latter. This leads to an enhancement of aerobic processes in
the brain and skeletal muscle tissues and of anaerobic processes in the liver and myocardium. Semiforced alcoholization of
rats during 11 months, with ethanol solution serving as the only soruce of liquid, moderately lowers the ethanol tolerance
and does not affect the dehydrogenase activity in the tissues examined. The effects of ethanol on the activity of functionally
associated enzyme systems of malate and lactate dehydrogenases are believed to depend on the method of alcoholization and
the type of tissue.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
, 7, pp. 107–109, July, 1994
Presented by A. N. Klimov, Member of the Russian Academy of Medical Sciences |
