托吡酯加添治疗难治性癫(癎)的临床研究

目的:观察托吡酯(TPM)对难治性癫的疗效和不良反应。方法:对114例难治性癫患者加用TPM治疗,观察控制癫发作效果。结果:TPM加添治疗总有效率为63.2%,儿童组有效率为62.5%,成人组为63.6%,对各型难治性癫均有效。TPM加添治疗起效时间在4～8周达高峰,有效率为43.4%。副作用发生率为25.4%,均较轻。结论:TPM加添治疗难治性癫疗效较好,是一种广谱、安全、耐受性好的新型抗癫药。

Clinical investigation of topiramate as an add on therapy in patients with epilepsy

Objective:To observe and evaluate the therapeutical effect and the side effect of topiramate(TPM)as an add on the therapy in patients with intractable epilepsy(IE).Methods:TPM was given as an add on therapy in 114 patients with IE.Results:As add on therapy,the effectiveness of TMP was 63.2%.In the children group,the effectiveness was 62.5% and in the adult group,that was 63.6%.The add on therapy of TPM was effective to all types of the seizure.The efficacy of TMP reached its peak after 4-8 week of treatment.The side effect of this drug was rather weak and the incidence of it was 25.4%.Conclusions:TPM give play a satisfactory effect as add on therapy in the patients with IE.It is a new broad spectrum,safe and well tolerated antiepileptic drug.