急性糖负荷对单纯高脂血症患者炎症及氧化应激反应的影响

目的研究急性糖负荷后,单纯高脂血症患者血清炎症及氧化应激标志物水平的变化。方法单纯高脂血症患者(HLP组)55例及健康对照者(Con组)54例,进行口服葡萄糖耐量试验(OGTT),检测空腹及OGTT-2 h血清炎症因子C-反应蛋白(CRP),肿瘤坏死因子-α(TNF-α)及白介素-6(IL-6),氧化应激指标丙二醛(MDA),过氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)的水平。结果与对照组相比,空腹及OGTT-2 h时,HLP组血清CRP、TNF-α、IL-6和MDA水平升高,SOD和GSH-Px水平下降(P<0.001或P<0.05)。与空腹时相比,HLP组血清CRP、TNF-α、IL-6水平在OGTT-2 h时增高(P<0.05),SOD和GSH-Px水平降低(P<0.001,P<0.05);而对照组仅血清IL-6水平在OGTT-2 h时升高(P<0.05),MDA、SOD和GSH-Px水平下降(P<0.001,P<0.05)。结论急性糖负荷能够进一步加剧恶化高脂血症患者体内的炎症及氧化应激反应,可能在高脂血症致动脉粥样硬化等慢性疾病的发生发展中发挥了重要的作用。

EFFECTS OF ACUTE GLUCOSE LOADING ON INFLAMMATION AND OXIDATIVE STRESS IN PATIENTS WITH SIMPLE HYPERLIPIDEMIA

Objective To study the changes in inflammatory factors and markers of oxidative stress after acute glucose loading in patients with simple hyperlipidemia.Method Fifty-five patients with simple hyperlipidemia(HLP group) and 54 healthy persons(Con group) were investigated.All subjects underwent oral glucose tolerance test(OGTT).Serum inflammatory factors including C-reactive protein(CRP),tumour necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and markers of oxidative stress including malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) were determined at fasting state and OGTT-2 h.Results At fasting state and OGTT-2 h,serum levels of CRP,TNF-α,IL-6 and MDA were increased,and serum levels of SOD and GSH-Px were decreased in HLP group(P<0.001 or P<0.05),as compared with Con group,respectively.For HLP subjects,serum levels of CRP,TNF-α and IL-6 at OGTT-2 h were increased(P<0.05),and serum levels of SOD and GSH-Px were decreased(P<0.001,P<0.05),as compared with fasting state.For healthy control subjects,serum level of IL-6 at OGTT-2 h was increased(P<0.05),and levels of MDA,SOD and GSH-Px were decreased(P<0.001,P<0.05),as compared with fasting state.Conclusion The inflammatory reaction and oxidative stress in patients with simple hyperlipidemia are further aggravated by acute glucose loading,which may play a important role in development of chronic diseases(such as atherosclerosis) caused by hyperlipidemia.