调控P-糖蛋白介导的肿瘤多药耐药的相关信号转导通路及其临床意义

多药耐药现象最初发现于肿瘤细胞，它是导致肿瘤药物化疗失败的最主要原因之一。在药物转运系统中，细胞膜上的外排转运体P-糖蛋白是外排细胞内药物从而导致肿瘤细胞多药耐药的最主要转运体之一。此外，某些信号转导通路参与了P-糖蛋白介导的肿瘤细胞多药耐药，例如丝裂原活化蛋白激酶信号转导通路、环核苷酸依赖性蛋白激酶信号转导途径、核因子XB信号通路、磷脂酰肌醇3激酶／蛋白激酶B信号通路和蛋白激酶c信号转导通路等等。本文对：参与调控P-糖蛋白介导肿瘤细胞多药耐药的相关信号转导通路及其临床意义进行综述。

Research and Clinical Significance of Relevant signalTransduction Pathways Involved inP-glycoprotein-mediated Multidrug Resistance

Multidrug Resistance （MDR）, first discovered in cancer cells, acts as an influential role in the failure of chemotherapy. P-glycoprotein, an efflux transporter on plasma membrane leads to MDR by pumping out intracellular drugs. What＇s more, further study indicate that some signal transduction pathways are involved in the Pgp-mediated MDR, which include mitogen-activated protein kinase, c-Jun NH2-terminal kinase, cyclic adenosine monophosphate dependent protein kinase, nuclear factor-kappa B and protein kinase C signaling pathways et al. Therefore, this review aims to elucidate the research advances as well as clinical significance of relevant signal transduction pathways involved in P-glycoprotein-mediated multidrug resistance.