单纯疱疹病毒Ⅰ型潜伏感染的研究——兔三叉神经节致敏T淋巴细胞检测研究

报告应用抗兔致敏T淋巴细胞的单克隆抗体和ABC免疫组织化学技术对22只实验性单纯疱疹病毒性角膜炎的家兔三叉神经节致敏T淋巴细胞检测的结果，首次揭示在角膜原发感染HSV-I过程中三叉神经节内致敏T淋巴细胞的出现。致敏T淋巴细胞在角膜接种后第13天出现。第85天消失，结果表明：T淋巴细胞在TG内HSV-I潜伏感染的建立过程中起重要作用。本研究对指导临床治疗提供了理论依据。

Studies on Latent Infection of Herpes Simplex Virus Type 1: Investigation on T Lymphocytes in the Trigeminal Ganglia of Rabbits

This paper reports that the trigeminal ganglia of 22 rabbits undergoing primary herpes simplex keratitis were stained for sensitized T lymphocytes with monoclonal antibody specific for rabbit sensitized T lymphocytes and ABC immunohistochemical techniques. The results of this investigation reveal,for the first time, the presence of sensitized T lymphocytes in the trigeminal ganglia of rabbits after primary corneal infection with herpes simplex virus type 1. Infiltration of T cells into the trigeminal ganglia was evident at 13 days after primary ocular infection but these cells had gone at 85 days after infection This investigation demonstrates that the T lymphocyte plays an important role in the establishment of HSV-1 latency in trigeminal ganglia. This investigation provides theoretical evidence for clinical therapy.