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Investigating a common approach to DNA profile interpretation using probabilistic software
Institution:1. ESR, Private Bag 92021, Auckland 1142, New Zealand;2. Forensic Science South Australia, 21 Divett Place, Adelaide, SA 5000, Australia;3. School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA, Australia;1. Netherlands Forensic Institute, Division of Biological Traces, Laan van Ypenburg 6, 2497GB, The Hague, The Netherlands;2. Netherlands Forensic Institute, Division of Digital and Biometric Traces, The Hague, The Netherlands;3. National forensic laboratory, Police, Ministry of the Interior, Ljubljana, Slovenia;4. Institute of Legal Medicine, Medical University of Innsbruck, Austria;5. Forensic Science Program, The Pennsylvania State University, University Park, PA, USA;6. Institut National de Police Scientifique, Ecully, France;7. Institute of Legal Medicine, University Hospital of Cologne, Division of Forensic Molecular Genetics, Cologne, Germany;1. Institute of Environmental Science and Research Limited, Private Bag 92021, Auckland, 1142, New Zealand;2. University of Auckland, Department of Statistics, Auckland, New Zealand;3. Center for Human Identification, Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, 76107, USA;1. Center for Human Identification, Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA;2. Institute of Environmental Science and Research Limited, Private Bag 92021, Auckland, 1142 New Zealand;1. Forensic Science South Australia, 21 Divett Place, Adelaide, SA 5000, Australia;2. School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia;3. ESR, Private Bag 92021, Auckland 1142, New Zealand;4. National Institute of Standards and Technology, 100 Bureau Drive, MS 8980 and 8314, Gaithersburg, MD 20899, United States of America;1. Mixture Commission of the GHEP-ISFG (The Spanish and Portuguese Speaking Working Group of the International Society for Forensic Genetics), Spain;2. INTCF – National Institute of Toxicology and Forensic Science, Department of Madrid, Spain;3. INTCF – National Institute of Toxicology and Forensic Science, Department of Barcelona, Spain;4. Instituto de Medicina Legal y Ciencias Forenses de Valencia, Spain;5. Laboratory of Forensic and Population Genetics, Toxicology and Health Legislation Department, Medicine School, Complutense University of Madrid, Spain;6. Laboratorio di Genetica Forense della Sezione di Medicina Legale dell''Istituto di Sanità Pubblica, Università Cattolica del Sacro Cuore di Roma, Italy;7. Department of Biomedical and Surgical Science, Section of Legal Medicine and Forensic Science, University of Perugia, “S. Maria” Hospital Terni, Italy;8. Institute of Criminalistics Prague, Prague, Czech Republic;9. INTCF – National Institute of Toxicology and Forensic Science, Department of Sevilla, Spain;10. Forensic Science Unit (FSU), Forensic Genetics Section, Basque Country Police, Erandio, Bizkaia, Spain;11. Departamento de Biología, Servicio de Criminalística de la Guardia Civil, Madrid, Spain;12. Registro Nacional ADN, Servicio Médico Legal, Santiago de Chile, Chile;13. INTCF – National Institute of Toxicology and Forensic Science, Delegation of Canarias, Santa Cruz de Tenerife, Spain;14. Unitat Central de Laboratori Biològic, Àrea Central de Criminalística, Divisió de Policia Científica, Policia de la Generalitat, Mossos d’Esquadra, Spain;15. Servicio de Genética Forense, Instituto de Ciencias Forenses, Universidad de Santiago de Compostela, Spain;p. Área de Laboratorio, NASERTIC, Navarra, Spain;q. Serviço de Genética e Biologia Forenses, INMLCF, IP, Delegação do Nort. Porto, Portugal;r. Serviço de Genética e Biologia Forenses, Instituto Nacional de Medicina Legal e Ciências Forenses, I.P., Coimbra, Portugal;s. Grupo Investigación Identificación Genética IdentiGEN, Universidad de Antioquia, Medellín, Colombia;t. Laboratorio Regional de Genética Forense del NOA, Departamento Médico, Poder Judicial de Jujuy, Jujuy, Argentina;u. Serviço de Genética e Biologia Forenses, Instituto Nacional de Medicina Legal e Ciências Forenses, Delegação Sul, Lisboa, Portugal;v. Unidad de Parentesco e Identificación Humana por ADN, Referencia Laboratorio Clínico, Dominican Republic;w. Servicio de Huellas Digitales Genéticas y Cátedra de Genética Forense. Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires, Argentina;x. Unidad de Genética Forense, Servicio Médico Legal de Santiago, Chile;y. Laboratorio Regional de Genética Forense, Poder Judicial de Rio Negro, Argentina;1. DNA Support Unit, Federal Bureau of Investigation Laboratory, 2501 Investigation Parkway, Quantico, VA 22135, USA;2. Biometrics Analysis Section, Federal Bureau of Investigation Laboratory, 2501 Investigation Parkway, Quantico, VA 22135, USA;3. Institute of Environmental Science and Research, Private Bag 92021, Auckland 1025, New Zealand;4. National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA;5. Forensic Science South Australia, 21 Divett Place, Adelaide, SA 5000, Australia;6. School of Biological Sciences, Flinders University, GPO Box 2100 Adelaide, SA, 5001 Australia
Abstract:Recently there has been a drive for standardisation of DNA profile interpretation within and between different forensic laboratories. The continuous interpretation software STRmix? has been adopted for use by laboratories in Australia and New Zealand for profile interpretation. Within this paper we examine the concordance in profile interpretation of three crime samples by twenty different analysts across twelve different international laboratories using STRmix?. The three profiles selected for this study exhibited a range of template and complexity. The use of probabilistic software has compelled a level of concordance between different analysts however there remain differences within profile interpretation, particularly with the objective assignment of the number of contributors to profiles.
Keywords:Forensic DNA interpretation  STRmix?  Mixed DNA profile  Standardisation
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