Robust detection of individual forensic profiles in DNA mixtures |
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| Affiliation: | 1. URX, 168 South Park St., San Francisco, CA 94107, United States;2. MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States;1. Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8005, USA;2. Department of Forensic Sciences, The George Washington University, 2100 Foxhall Road, NW, Washington, D.C., 20007, USA;3. Human Identification Group, ThermoFisher Scientific, 180 Oyster Point Blvd, South San Francisco, CA, 94080, USA;1. Graduate Institute of Biotechnology, National Chung Hsing University, 250 Kuo Kuang Road, South District, Taichung City 40227, Taiwan, ROC;2. Taichung City Government Police Department, 588 Wenxin Road Section 2, Xitun District, Taichung City 40758, Taiwan, ROC;3. Department of Forensic Science, Central Police University, 56 Shu-Jen Road, Kwei-San, Taoyuan 33304, Taiwan, ROC;4. Department of Forensic Medicine, College of Medicine, National Taiwan University, 1 Jen-Ai Road Section 1, Taipei 10051, Taiwan, ROC;5. Forensic Biology Division, Criminal Investigation Bureau, National Police Agency, 5 Lane 553, Zhongxiao East Road Section 4, Xinyi District, Taipei 11072, Taiwan, ROC;6. School of Biological Sciences, Flinders University, Adelaide 5001, Australia;1. Netherlands Forensic Institute, P.O. Box 24044, 2490 AA The Hague, The Netherlands;2. VU University Amsterdam, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands;1. Institute of Environmental Science and Research Limited, Private Bag 92021, Auckland, 1142, New Zealand;2. Forensic Science SA, GPO Box 2790, Adelaide, SA, Australia;3. School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA, 5001, Australia;4. University of Auckland, Department of Statistics, Auckland, New Zealand |
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| Abstract: | For a forensic identification method to be admissible in international courts, the probability of false match must be quantified. For comparison of individuals against complex mixtures using a panel of single nucleotide polymorphisms (SNPs), the probability of a random man not excluded, P(RMNE) is one admissible standard. While the P(RMNE) of SNP alleles has been previously studied, it remains to be rigorously defined and calculated for experimentally genotyped mixtures. In this report, exact P(RMNE) values were calculated for a range of complex mixtures, verified with Monte Carlo simulations, and compared alongside experimentally determined detection probabilities. |
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| Keywords: | Single nucleotide polymorphism (SNP) DNA mixture Random man not excluded (RMNE) |
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