Expanding X-chromosomal forensic haplotype frequencies database: Italian population data of four linkage groups |
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| Institution: | 1. Department of Medical and Surgical Sciences, DIMEC, Institute of Legal Medicine, University of Bologna, Italy;2. Department of Biological, Geological and Environmental Sciences, BIGEA, Laboratory of Molecular Anthropology, University of Bologna, Italy;1. Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai 200083, China;2. Key Laboratory of Forensic Evidence and Science Technology, Ministry of Public Security, Institute of Forensic Science, Shanghai Public Security Bureau, North Zhongshan No. 1 Road 803, Shanghai 200083, China;3. State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200438, China;1. Institute of Applied Genetics, Department of Molecular and Medical Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Blvd. Fort Worth, TX 76107, USA;2. Department of Chemistry Malaysia Kuching, Ministry of Science, Technology and Innovation (MOSTI) Malaysia;3. Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia;1. Department of Family Genetics, Norwegian Institute of Public Health, P.O. Box 4040 Nydalen, NO-0403 Oslo, Norway;2. Department for Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Aas, Norway;3. Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Artillerigatan 12, SE-587 58 Linköping, Sweden;4. Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden;1. Institute of Legal Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;2. Human Genetics Laboratory, University of Madeira, Campus of Penteada, 9020-105 Funchal, Portugal;3. Genetic Department, Institute of Biology, State University of Rio de Janeiro (UERJ), Brazil;1. DNA Analysis Laboratory, Natural Sciences Research Institute, University of the Philippines Diliman, Philippines;2. Philippine Genome Center, University of the Philippines, Philippines;3. Balik Scientist, Philippine Council for Industry, Energy and Emerging Technology Research and Development – Department of Science and Technology, Philippines;1. University Department for Forensic Sciences, University of Split, Split, Croatia;2. Ru?er Bo?kovi? Institute, Zagreb, Croatia;3. Forensic Science Centre “Ivan Vu?eti?”, Zagreb, Croatia;4. Forensic Science Office, University of Zagreb, Zagreb, Croatia;5. Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia |
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| Abstract: | Requests for solving complex kinship casework involving at least one female are increasing and in these circumstances the analysis of X-chromosomal STR markers plays a relevant role. Actually, it is well known the superior statistical power of X-STRs compared to autosomal markers in solving relationship when two sisters or half-sisters are involved and none of parents is available, in maternity testing or in cases involving close relatives as alternative putative fathers. In addition, the possibility to amplify more loci simultaneously and the strategy based on the analysis of four linkage groups to obtain the X-haplotype provide a powerful and validated tool. Nevertheless, haplotypes frequency distribution in different populations is still needed for calculation of probabilities in relationship testing. Published haplotype frequencies from German population data are available, but in different caseworks we found unreported X-haplotypes. To enlarge the forensic X-chromosome database, we present haplotype frequencies and other parameter of forensic interest obtained from 200 anonymous DNA samples of unrelated Italian males for the four linkage groups included in the Investigator Argus X-12 kit. From the comparison of the Italian sample haplotype frequencies with other populations, significant genetic distances were found with Asian and African populations, but not with Europeans. Finally, casework examples of complex kinship analysis are presented. |
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| Keywords: | X-chromosome Investigator Argus X-12 STR markers Haplotype frequencies Kinship analysis |
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