Vitamin E attenuates alcohol-induced aortic wall damage in rats |
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| Affiliation: | 1. Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;2. Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;3. Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran;1. Annenberg Public Policy Center, University of Pennsylvania, 202 South 36th Street, Philadelphia, PA, 19104, USA;2. Department of Health Policy and Management, Texas A&M University, USA;3. History & Political Science Department, Utah Valley University, USA;1. Department of Biochemistry, Memorial University of Newfoundland, St. John’s, NL, A1B3X9 Canada;2. Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, 01246-904, Brazil;3. Laboratory of Antioxidants, Nutrition and Food Technology Institute, University of Chile, Santiago, Chile;4. School of Kinesiology, Faculty of Medicine, Universidad Finis Terrae, Santiago, Chile;1. School of Sports and Health, Nanjing Sport Institute, Nanjing, 210014, China;2. Jiangsu Collaborative Innovation Center for Sport and Health Project, Nanjing, 210014, China;1. Department of Physical Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008, Russian Federation;2. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov Str. 8, Kazan 420088, Russian Federation;3. Department of Organic and Medicine Chemistry, Kazan Federal University, Kremlevskaya 18, Kazan 420008, Russian Federation |
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| Abstract: | BackgroundIn this study the effect of chronic ethanol consumption on vascular wall abnormality via oxidative stress was examined. It was also intended to find out whether vitamin E inhibits the abnormality induced by ethanol in rat vascular wall.MethodsTwenty-four male wistar rats were divided into three groups, namely, control, ethanol (4.5 g/kgBW intragastrically), and vitamin E treated ethanolic groups(VETE) (300 mg interagastrically).ResultsAfter 6 weeks treatment of rats, the results revealed that along with a significant increase VSMC proliferation and aorta wall thickness with the increase in the level of Ox-LDL, protein carbonyl, as well as decrease total antioxidant capacity in animal that received ethanol compared to the control group. Significant amelioration of aorta wall changes, along restoration of the elevated level of Ox-LDL, protein carbonyl, lipid profile, and decreased level of total antioxidant capacity to that of controls were found in vitamin E-treated animals.ConclusionsThese findings strongly support the idea that heavy and chronic ethanol consumption initiate atherosclerosis by oxidative stress, and that these effects can be alleviated by vitamin E as an antioxidant. |
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| Keywords: | Ethanol Rat Oxidative stress Vascular Vitamin E |
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