The cortisol,serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder |
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| Affiliation: | 1. KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway;2. Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway;3. Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Faculty of Medicine, University of Oslo, Oslo, Norway;4. Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Norway;5. Department of Medical Genetics, Oslo University Hospital Ullevål, Oslo, Norway;6. Department of Radiology, University of California San Diego, La Jolla, CA, USA;7. Department of Neuroscience, University of California San Diego, La Jolla, CA, USA;8. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA;1. Shandong University School of Public Health, Center for Suicide Prevention Research, Jinan 250012, China;2. State University of New York Buffalo State, Buffalo, NY 14222, USA;3. Center for Disease Prevention and Control of Shizhong District of Jinan, Jinan 250022, China |
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| Abstract: | Repetitive behaviors (RBs) are a core feature of autism spectrum disorders (ASD). They constitute a major barrier to learning and social adaptation. Research on potential causes of RBs is still at an early stage. However, promising new ideas and evidence are emerging from neurobiology. Instead of testing single neurotransmitter or hormone, the present study examined the associations of cortisol, serotonin, and oxytocin on subscales of repetitive behavior scales-revised (RBS-R). The results demonstrated that the individuals with ASD showed higher levels of cortisol areas under curve (cortisol AUC), higher levels of serotonin, and lower level of oxytocin compared with the typically developing (TD) individuals. For individuals with ASD, the levels of cortisol AUC, serotonin and oxytocin were all significantly associated with total scores measured by RBS-R. In addition, the cortisol AUC was positively associated with the stereotyped and restricted behavior subscales scores. The level of serotonin was positively associated with the stereotyped and self-injurious behavior subscales scores. The level of oxytocin was negatively associated with compulsive, sameness and restricted behavior subscales scores. Therefore, cortisol, serotonin and oxytocin may all be involved in the occurrence of RBs in ASD. The occurrence of RBs in ASD may due to a variety of pathological factors, not just one factor. |
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| Keywords: | Autism spectrum disorders Repetitive behaviors Cortisol Serotonin Oxytocin |
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