| 醒脑静对大鼠皮层神经细胞的保护作用 |
| |
| 引用本文： | 万文成,李杰芬,罗海燕,李小英,张少琼. 醒脑静对大鼠皮层神经细胞的保护作用[J]. 广州中医药大学学报, 2002, 19(2): 125-126 |
| |
| 作者姓名： | 万文成 李杰芬 罗海燕 李小英 张少琼 |
| |
| 作者单位： | 广州中医药大学基础医学院,广州,510405 |
| |
| 摘 要： | [目的]研究麝香、冰片等组成的醒脑静对神经细胞的保护作用。[方法]利用原代培养的大鼠大脑皮层神经细胞,观察醒脑静对抗谷氨酸(10μmol·L-1,3h)对脑细胞的兴奋毒性作用。[结果]醒脑静能减少谷氨酸所造成的细胞内乳酸脱氢酶漏出量,减轻细胞的形态学改变。[结论]醒脑静能够对抗谷氨酸介导的兴奋性毒性,对培养的大鼠大脑皮层细胞具有保护作用。
|
| 关 键 词： | 醒脑静 药理学 神经元 药物作用 麝香 冰片 中药 |
| 文章编号： | 1007-3213(2002)02-0125-02 |
| 修稿时间： | 2002-03-05 |
Protective Effect of Xing Nao Jing on Cultured Cortical Neurons in Rats |
| |
| WAN Wencheng,LI Jiefen,WO Haiyan,LI Xiaoying,ZHANG Shaoqiong. Protective Effect of Xing Nao Jing on Cultured Cortical Neurons in Rats[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2002, 19(2): 125-126 |
| |
| Authors: | WAN Wencheng LI Jiefen WO Haiyan LI Xiaoying ZHANG Shaoqiong |
| |
| Abstract: | [Objective] To study the protective effect of Xing Nao Jing (XNJ) on cultured cortical neurons in rats. [Methods] Primary cultured cortical neurons were applied to observe the effect of XNJ in counteracting the excitotoxicity ofglutamic acid. [Results] XNJ decreased the release of intracellular lactic dehydrogenase induced by glutamic acid and reduced the histological changes of cultured cortical neurons. [Conclusion] XNJ can counteract the excitotoxicity of glutamic acid and protect cultured cortical neurons in rats. |
| |
| Keywords: | XING NAO JING/phamiacology NEURONS/drug effects MOSCHUS/pharmacology BORNEOLUM SYNTHETICUM /pharmacology |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
