| 1,2-二甲基-3-羟基-4-吡啶酮遗传毒性的研究 |
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| 引用本文： | 吴世德,刘萍,冯国昌,禚金花,姚玉娜. 1,2-二甲基-3-羟基-4-吡啶酮遗传毒性的研究[J]. 癌变．畸变．突变, 2007, 19(1): 47-49. DOI: 10.3969/j.issn.1004-616X.2007.01.014 |
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| 作者姓名： | 吴世德 刘萍 冯国昌 禚金花 姚玉娜 |
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| 作者单位： | 1. 山东省生物药物研究院,山东,济南,250014;2. 山东大学公共卫生学院卫生,检验所,山东,济南,250012 |
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| 基金项目： | 山东省科技厅资助项目（012100104）,济南市青年科技明星计划（200205） |
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| 摘 要： | 背景与目的:研究1,2-二甲基-3-羟基-4-吡啶酮(DHPO)的急性毒性及不同剂量、不同时间的遗传毒性.材料与方法:采用昆明种小鼠,先进行LD50试验,然后对高(1/2 LD50)、中(1/4 LD50)、低(1/8 LD50)DHPO剂量组进行外周血和骨髓微核率的观察.结果:DHPO的小鼠经口LD50为562.34 mg/kg.外周血和骨髓微核试验显示,1/8 LD50(70 mg/kg)组、1/4 LD50(140 mg/kg)组微核率与阴性对照组相比差异均无统计学意义(P＞0.05);1/2 LD50(280 mg/kg)组微核率高于阴性对照组、1/8 LD50(140 mg/kg)组和1/4 LD50组(P均＜0.05).结论:DHPO属于低毒药物,具有小鼠体内染色体畸变的遗传毒性.
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| 关 键 词： | 1,2-二甲基-3-羟基-4-吡啶酮 LD50 骨髓多染红细胞 微核试验 |
| 文章编号： | 1006-616X（2007）01-0047-03 |
| 收稿时间： | 2006-02-15 |
| 修稿时间： | 2006-05-30 |
Preliminary Study of Inheritable Toxicity of t,2-dimethyl-3-hydroxypyrid-4-one in Mice |
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| WU Shi-de,LIU Ping,FENG Guo-chang,ZHUO Jin-hua,YAO Yu-na. Preliminary Study of Inheritable Toxicity of t,2-dimethyl-3-hydroxypyrid-4-one in Mice[J]. Carcinogenesis,Teratogenesis and Mutagenesis, 2007, 19(1): 47-49. DOI: 10.3969/j.issn.1004-616X.2007.01.014 |
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| Authors: | WU Shi-de LIU Ping FENG Guo-chang ZHUO Jin-hua YAO Yu-na |
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| Affiliation: | 1.Inatitute of Shandong Biological Medicines, Jinan 250014, China; 2. Department of Health Surveillance, College of Public Health, Shandong University, Jinan 250012, China |
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| Abstract: | BACKGROUND &AIM: To investigate the acute toxicity and the inheritable toxicity of 1,2-dimethyl-3-hydroxypyrid-4-one(DHPO) in mice. MATERIALS AND METHODS: LD50 test was performed ,then Kun Ming mice were given different oral doses of the DHPO to carry out the micronucleus test under low(1/8 LD50), mid (1/4 LD50), high(1/2 LD50) doses. RESULTS: LD50 of DHPO was 562.34 mg/kg peroral in mice. 1/2 LD50 group was different from the negative control in the micronucleus test(P<0.05), whereas no significant differences were observed among 1/4 LD50 , 1/8 LD50 groups and negative control(P>0.05). CONCLUSION: Our results suggested that DHPO had low toxicity but had inheritable toxicity to a certain extent. |
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| Keywords: | DHPO LD50 polychromatic erythrocyte micronucleus test |
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