Family history of gynaecological cancers |
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| Institution: | 1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Minnesota, Minneapolis, MN, USA;2. Department of Surgery, Park Nicollet Health System, St. Louis Park, MN, USA;3. Department of Pathology, Magee Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA;4. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Magee Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA;1. Centro de Excelencia en Geotermia de los Andes (CEGA) and Departamento Geología, Universidad de Chile, Santiago, Chile;2. Department of Earth and Atmospheric Sciences, University of Houston, TX, USA;3. Department of Earth Sciences, Durham University, UK |
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| Abstract: | Women are presenting to primary and secondary care with concerns about a family history of ovarian and breast cancer, or ovarian, endometrial and bowel cancer. Although most ovarian and endometrial cancer is sporadic, about 5?10% is due to mutations in genes which predispose to breast/ovarian cancers, BRCA1 and BRCA2, and ovarian/endometrial and bowel cancer, the mismatch repair genes of hereditary non-polyposis colon cancer (HNPCC). This review considers different scenarios in women presenting with a family history of ovarian and endometrial cancer. It uses these family histories to illustrate the ways in which families at high risk of ovarian and endometrial cancer can be identified by pedigree analysis. There will be further discussion about these genes and the different management options available to families, including surveillance, chemoprevention and prophylactic surgery. |
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