The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbutamide in man |
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| Authors: | T. Lysbo Svendsen M. Brandt Kristensen J. Mølholm Hansen L. Skovsted |
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| Affiliation: | (1) Medical Dept. C, Diakonissestiftelsen, and Medical Dept. F, Gentofte Hospital, Copenhagen, Denmark |
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| Abstract: | Summary Diphenylhydantoin (DPH) and tolbutamide serum levels were studied in ten volunteers before and after 4 days of disulfiram treatment. The mean DPH half life incresed significantly from 11.0±1.2 h to 19.0±3.3 h, and the mean DPH metabolic clearance rate decreased significantly from 51.2±17.2 ml/min to 33.9±12.0 ml/min during medication. No significant changes in the half life or metabolic clearance rate of tolbutamide was observed. |
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| Keywords: | Tolbutamide diphenylhydantoin drug interaction disulfiram clearance rate serum level |
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