| 2-苯基-1,3-丙二醇的制备 |
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| 引用本文： | 赵佩玲,张道明. 2-苯基-1,3-丙二醇的制备[J]. 中国医药工业杂志, 2010, 41(2) |
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| 作者姓名： | 赵佩玲 张道明 |
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| 作者单位： | 上海市医药学校,上海,200135 |
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| 摘 要： | 2-苯基-1,3-丙醇(1)可用于合成抗癲痫药非氨酯(felbamate)等~([1]).1的合成方法报道很多~([2-5]).其中文献~([2])用2-苯基丙二酸二乙酯(2)经硼氢化钠还原制得1,操作简便,但收率仅48.6%.
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Preparation of 2-Phenyl-1,3-propanediol |
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| ZHAO Peiling,ZHANG Daoming. Preparation of 2-Phenyl-1,3-propanediol[J]. , 2010, 41(2) |
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| Authors: | ZHAO Peiling ZHANG Daoming |
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| Abstract: | 2-Phenyl-1,3-propanediol was synthesized from diethyl phenylmalonate by reduction with calcium borohydride produced in situ from sodium borohydride and calcium chloride with a yield of 85%. |
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| Keywords: | 2-phenyl-1,3-propanediol intermediate preparation |
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