尤瑞克林联合阿替普酶对急性脑梗死的神经功能及炎症因子的影响

目的观察尤瑞克林联合阿替普酶溶栓治疗急性脑梗死的临床疗效及对血清炎症因子的影响。方法选择2017-07—2019-12河南科技大学第二附属医院神经内科收治的72例急性脑梗死患者,采用随机数表法分为2组,对照组36例在控制血压、血糖等基础上施予阿替普酶溶栓治疗,观察组36例在对照组基础上输注尤瑞克林注射液治疗,比较2组疗效、NIHSS评分及血清炎症因子水平变化。结果治疗后,观察组(94.4%)临床疗效优于对照组(75%),差异有统计学意义(P<0.05);神经功能恢复优于对照组,差异具有统计学意义(P<0.05);炎症因子水平低于对照组,差异具有统计学意义(P<0.05);2组均未见明显不良反应。结论急性脑梗死患者应用注射用尤瑞克林联合阿替普酶溶栓,利于改善临床预后,缓解炎性反应,减轻神经缺损,进而提高生活质量。

Effect of Urinary Kallidinogenase combined with alteplase on neurological function and serum stressors of patients with acute cerebral infarction

Objective To observe and analyze the efficacy of Urinary Kallidinogenase combined with alteplase on acute cerebral infarction(ACI)and its effects on neurological function and blood inflammatory factors.Methods A total of 72 patients with ACI in our hospital were selected and randomly divided into observation group and control group,with 36 cases in each group.The control group was given alteplase on the basis of conventional drugs,and the observation group was treated with Urinary Kallidinogenase on the basis of the control group.The total effective rate of treatment,and the recovery of brain neurological function and daily living ability,and blood inflammatory factors before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the recovery of neurological function in the observation group ere better than those of the control group(P<0.05).The levels of blood inflammatory actor in the observation group were significantly lower than those in the control group(P<0.05).No significant adverse reactions were observed in both groups.Conclusion Urinary Kallidinogenase combined with alteplase for ACI patients can effectively restore the brain neurological function,reduce blood inflammatory actors levels,and reduce nerve defect,which has improve the quality of life.