郑州市学龄前儿童血清25羟维生素D水平分析

目的分析郑州市学龄前儿童25羟维生素D(25-(OH)D)水平,为临床指导补充维生素D提供科学依据。方法分析2017年6月至2018年6月来院体检的0~6岁儿童25-(OH)D资料,采用电化学发光免疫分析法检测25-(OH)D水平。将研究对象按年龄,性别及不同季节进行分组分析。结果965例学龄前儿童血清25-(OH)D平均水平为(33.32±14.06)ng/mL,缺乏与不足占44.04%。不同年龄组相比,具有统计学意义(P<0.001),25-(OH)D水平及充足率随儿童年龄增长出现先升高后降低的趋势,其中1岁组最高,其次为6~11月龄。5岁组男童的25-(OH)D平均水平较女童偏高(P<0.05),其他各年龄组男女水平无统计学意义(P>0.05)。不同季节儿童25-(OH)D水平比较,夏季组最高,秋季组次之,春季组和冬季组明显较低(P<0.01)。结论郑州市学龄前儿童维生素D缺乏与不足比例较高,尤其2岁以上儿童维生素D营养状况令人堪忧。临床应加强儿童保健的科普宣教,根据维生素D营养状况指导用药,以降低儿童维生素D缺乏的发病率。

Analysis of serum 25 hydroxy vitamin D level of preschool children in Zhengzhou

Objective The purpose of this paper is to analyze the 25-(OH)D level of preschool children in Zhengzhou City, and to provide scientific basis for clinical guidance of vitamin D supplementation. Methods 25-(OH)D data of 0-6-year-old children from June 2017 to June 2018 were analyzed, and the level of 25-(OH)D was detected by electrochemiluminescence immunoassay. The subjects were grouped and analyzed according to age, gender and different seasons. Results The average level of serum 25-(OH)D in 965 preschool children was(33.32 ± 14.06) ng/mL,and the deficiency accounted for 44.04%. Compared with different age groups, there was significant difference(P <0.001), 25-(OH)D level and adequacy ratio increased first and then decreased with the growth of children’s age, among which the highest was in the 1-year-old group, followed by the 6-11-month-old group. The average level of 25-(OH)D of boys in 5-year-old group was higher than that of girls(P< 0.05), and there was no difference in the level of men and women in other age groups(P > 0.05). The 25-(OH)D level of children in different seasons was the highest in summer group, followed by autumn group, and significantly lower in spring group and winter group(P < 0.01).Conclusion The ratio of vitamin D deficiency and deficiency of preschool children in Zhengzhou is high, especially the nutritional status of vitamin D of children over 2 years old is worrying. We should strengthen the science popularization education for children’s health and guide the medication according to the nutritional status of vitamin D, so as to reduce the incidence rate of vitamin D deficiency in children.