镇心安神汤对老年性皮肤瘙痒症患者TH1/TH2型细胞因子、P物质水平的影响

目的:观察镇心安神汤对老年性皮肤瘙痒症患者的治疗效果,并观察其对患者血清TH1/TH2型细胞因子、P物质水平的影响。方法:106例老年性皮肤瘙痒症患者采用随机数字表法分为观察组和对照组,每组各53例。对照组给予氯雷他定片和维生素C治疗,观察组给予镇心安神汤治疗。两组均以4周为1个疗程,治疗1个疗程。比较两组患者治疗前后血清白细胞介素-2(interleukin,IL-2)、干扰素-γ(interferon-γ,IFN-γ)、IL-4、IL-5、IL-10、IL-13和P物质水平,临床症状和中医证候进行评分,观察不良反应发生情况,评价疗效和复发情况。结果:治疗后,两组患者血清IL-2、IFN-γ、P物质水平均明显低于治疗前,IL-4、IL-5、IL-10、IL-13水平较治疗前明显升高(P<0.05);观察组患者血清IL-2、IFN-γ、P物质水平低于对照组,IL-4、IL-5、IL-10、IL-13水平高于对照组(P<0.05)。治疗后,两组患者各项临床症状评分和总分以及中医证候评分均明显低于治疗前(P<0.05);观察组患者各项临床症状评分和总分以及中医证候评分均低于对照组(P<0.05)。观察组患者有效率为90.57%,高于对照组的73.58%(P<0.05)。观察组患者复发率为11.11%,低于对照组的35.71%(P<0.05);观察组患者不良反应发生率为16.98%,低于对照组的35.85%(P<0.05)。结论:镇心安神汤能够显著改善老年性皮肤瘙痒症患者症状,疗效显著,不良反应少、复发率低,其作用机制可能是通过调节TH1/TH2细胞因子平衡和P物质水平发挥作用的。

Effect of Zhenxin Anshen Decoction on Th1/Th2 Type Cytokines Level and Substance P in Senile Pruritus Patients

Objective:To observe the therapeutic effect of Zhenxin Anshen Decoction on senile pruritus patients,and to observe its effect on Th1/Th2 type cytokines and substance P in serum.Methods:106 cases of senile pruritus patients were randomly divided into observation group and control group,53 cases in each group.The control group was treated with loratadine and vitamin C,and the observation group was treated with Zhenxin Anshen Decoction.Two groups of patients were treated with 4 weeks as a course of treatment,one course of treatment.The serum levels of interleukin(IL-2),interferon-γ(IFN-γ),IL-4,IL-5,IL-10,IL-13 and substance P,clinical symptoms and TCM syndromes were compared before and after treatment.The adverse reactions were observed and the therapeutic effect and recurrence were evaluated.Results:After treatment,the serum levels of IL-2,IFN-γand substance PP in the two groups were significantly lower than those before treatment,and the levels of IL-4,IL-5,IL-10 and IL-13 were significantly higher than those before treatment(P<0.05);the serum levels of IL-2,IFN-γand substance P in the observation group were lower than those in the control group,and the levels of IL-4,IL-5,IL-10 and IL-13 in the observation group were higher than those in the control group(P<0.05).After treatment,the scores of clinical symptoms and TCM syndrome in the two groups were significantly lower than those before treatment(P<0.05);the scores of clinical symptoms and TCM syndrome in the observation group were lower than those in the control group(P<0.05).The effective rate of observation group was 90.57%,which was higher than that of control group(73.58%)(P<0.05).The recurrence rate was 11.11%in the observation group,which was lower than 38.46%in the control group(P<0.05);the incidence of adverse reactions in the observation group was 16.98%,which was lower than that in the control group(P<0.05).Conclusion:Zhenxin Anshen Decoction can significantly improve the symptoms of elderly patients with pruritus.It has significant curative effect,few adverse reactions and low recurrence rate.Its mechanism may be through regulating Th1/Th2 cytokine balance and substance P level.