中性粒细胞/淋巴细胞比值及空腹血糖对急性脑出血患者短期死亡的评估作用

目的探讨中性粒细胞/淋巴细胞比值及空腹血糖在脑出血患者短期死亡评估中的作用。方法选取2016-06-01—2018-05-31在郑州大学第一附属医院神经内科住院诊疗的189例急性脑出血患者为研究对象,选取同期健康体检者189例为参照组,单因素分析2组临床及实验室资料;发病30 d时统计生存与死亡人数,分为生存组与死亡组,单因素分析2组临床、影像学及实验室资料,采用多因素Logistic回归分析统计影响急性脑出血短期死亡的危险因素,采用受试者工作特征(receiver operating characteristic,ROC)曲线评价NLR和FBG对短期死亡的预测价值。结果急性脑出血组与对照组比较,NLR(5.67±1.53 vs 4.01±1.53)和FBG(7.07±2.47 vs 5.59±1.89)差异有统计学意义(P<0.05);死亡组与存活组比较,NLR(6.82±1.04 vs 5.52±1.46)和FBG(10.06±2.51 vs 6.69±2.21)差异有统计学意义(P<0.05);多因素Logistic回归分析显示,WBC、FBG、NLR、GCS与急性脑出血发病30 d时的死亡独立相关(P<0.05);ROC曲线分析表明,NLR和FBG的ROC曲线下面积(AUC)分别为0.777(95%CI0.667~0.877,P<0.01)、0.864(95%CI0.792~0.937,P<0.01)。结论NLR和FBG是预测急性脑出血患者短期死亡的独立危险因素。

Prognostic value of neutrophil to lymphocyte ratio and plasma glucose for short-term mortality in patients with acute intracerebral hemorrhage

Objective To explore the Prognostic value of neutrophil to lymphocyte ratio and plasma glucose for short-term mortality in patients with acute intracerebral hemorrhage.Methods From June 1st 2016 to June 31st 2018,189 patients with AICH were selected as the research subjects.189 cases with healthy physical examination in the same period were selected as control group,univariate analyses were conducted to analyze the clinical and laboratory data of both groups.They were divided into survival group and death group at 30 days after onset.Univariate analyses were conducted to analyze the clinical,imaging and laboratory data of both groups.The multivariate Logistic regression analysis was performed to analyze the risk factors indicating short-term mortality.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of NLR and FBG for short-term mortality.Results Compared with the control group,the NLR and FBG were higher in research group(5.67±1.53 vs 4.01±1.53)and(7.07±2.47 vs 5.59±1.89);NLR(6.82±1.04 vs 5.52±1.46)and FBG(10.06±2.51 vs 6.69±2.21)were higher in the death group than the survival group(P<0.05).The multivariate Logistic regression analysis results showed that WBC,FBG,NLR and GCS were the independent risk factors of 30-day mortality in acute intracerebral hemorrhage patients(P<0.05).ROC curve analysis indicated that the areas under the ROC curve of NLR and FBG were 0.777(95%CI0.667-0.877,P<0.01),0.864(95%CI0.792-0.937,P<0.01).Conclusion NLR and FBG were independent risk factors to predict the 30-day mortality in acute intracerebral hemorrhage patients.