超声造影评估斑块稳定程度与基础血脂水平的相关性分析

目的探究颈动脉粥样硬化斑块稳定性与基础血脂水平的相关性。方法收集山西医科大学第二医院住院时诊断为颈动脉粥样硬化斑块形成的且未曾降脂干预的患者22例,总共54个斑块,所有患者通过常规超声确诊为颈动脉粥样硬化斑块形成后,再进行颈动脉超声造影检查,并分别检测患者的基础TC、TG、LDL、HDL,进一步分析斑块的稳定程度与基础血脂水平的关系。结果54个斑块超声造影分级0级为4个;1级为8个;2级为12个;3级为18个;4级为12个,22例患者平均基础LDL、HDL、TG、TC水平分别为(2.78±0.47)mmol/L、(1.12±0.23)mmol/L、(1.75±0.93)mmol/L、(4.82±0.61)mmol/L,不同斑块的超声造影分级与基础TC水平呈显著相关性(P=0.034<0.05,r=0.289),与基础LDL水平呈显著相关性(P<0.001,r=0.520),与基础HDL水平呈显著相关性(P=0.009<0.05,r=-0.353),与基础TG水平无相关性(P=0.799>0.05)。结论基础低密度脂蛋白、基础总胆固醇越高、基础高密度脂蛋白水平越低,斑块的稳定性越差。

Correlation analysis between the stability of atherosclerotic plaque and basal blood lipid level by carotid contrast-enhanced ultrasonography

Objective To explore the correlation between the stability of atherosclerotic plaque and basal blood lipid level.Methods Collect data from 22 patients that were hospitalized in Second Hospital of Shanxi Medical University for carotid atherosclerotic plaque and they never performed lipid-lowering treatment.There are 54 atherosclerotic plaques in all.All patients were diagnosed to have carotid atherosclerotic plaque by carotid artery ultrasound.Then they continued to examine by carotid contrast-enhanced ultrasonography.And then,basal low-density lipoprotein level,basal high-density lipoprotein level,basal triglyceride level and basal total cholesterol level were measured to analyze the correlation between the stability of atherosclerotic plaque and basal blood lipid level.Results carotid contrast-enhanced ultrasonography levels of 54 carotid atherosclerotic plaques4 is level 0;8 is level 1;12 is level 2;18 is level 3;12 is level 4.The average basal low-density lipoprotein,high-density lipoprotein,triglyceride and total cholesterol levels of 22 patients were(2.78±0.47)mmol/L,(1.12±0.23)mmol/L,(1.75±0.93)mmol/L,(4.82±0.61)mmol/L.The levels of ultrasound contrast of different plaques were significantly correlated with basal total cholesterol levels(P=0.034,r=0.289),were significantly correlated with basal low-density lipoprotein levels(P<0.001,r=0.520),were significantly correlated with basal high-density lipoprotein levels P=0.009,r=-0.353),and had no correlation with basal triglyceride levels(P=0.799).Conclusion Basal low density lipoprotein and basal total cholesterol are negatively correlated with the degree of atherosclerotic plaque stability,basal high-density lipoprotein is positively correlated with the degree of atherosclerotic plaque stability.