Analysis of a cell line derived from a chicken hepatoma induced by virus MC29 |
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| Authors: | V Sovova I Hlozanek H Cerna V Dostalova H Sainerova |
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| Affiliation: | Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague 6, Czechoslovakia. |
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| Abstract: | A cell line derived from a transplantable chicken hepatoma induced by virus MC29 was established. This cell line grew permanently over 2 years and could be easily recovered from frozen state. Morphology of cells did not change during the period of cultivation. Karyological analysis revealed the hypodiploid stemline with reduced numbers of microchromosomes. The cell line was not transplantable in 1-day-old chicks, but induced multiple tumour nodules in the mesenterium and liver about 8 weeks postinoculation. The cell line is virus productive. The analysis of viral proteins with the gag specific determinants showed the presence of pr76 and p110. |
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