| 雷贝拉唑钠中有机溶剂残留量的毛细管GC测定 |
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| 引用本文： | 邹向阳. 雷贝拉唑钠中有机溶剂残留量的毛细管GC测定[J]. 中国医药工业杂志, 2006, 37(1): 43-44 |
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| 作者姓名： | 邹向阳 |
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| 作者单位： | 南京工业大学制药与生命科学学院,江苏,南京,210009;丽珠集团常州康丽制药有限公司,江苏,常州,213105 |
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| 摘 要： | 建立了毛细管GC法测定雷贝拉唑钠中甲醇、乙醚、丙酮、二氯甲烷、乙酸乙酯、甲苯等6种有机溶剂的残留量。采用DB-624毛细管柱，程序升温。6种有机溶剂的平均回收率分别为100．4％、98．7％、100．3％、100．4％、100．2％和99．9％，检测限分别为0．6、1、1、2．4、1、2．8ng。
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| 关 键 词： | 雷贝拉唑钠 有机溶剂残留 毛细管气相色谱 测定 |
| 文章编号： | 1001-8255（2006）01-0043-02 |
| 收稿时间： | 2005-01-31 |
| 修稿时间： | 2005-01-31 |
Determination of Residual Organic Solvents in Rabeprazole Sodium by Capillary GC |
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| ZOU Xiang-Yang. Determination of Residual Organic Solvents in Rabeprazole Sodium by Capillary GC[J]. , 2006, 37(1): 43-44 |
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| Authors: | ZOU Xiang-Yang |
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| Affiliation: | 1. College of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009 ; 2. Livzon Group Changzhou Kony Pharmaceutical Co. Ltd., Changzhou 213105 |
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| Abstract: | A capillary GC method was established for determination of six residual solvents methanol, ether, acetone, methylene chloride, ethyl acetate, toluene in rabeprazole sodium. A DB-624 capillary column was used with temperature programmed control. The average recoveries were 100.4 %, 98.7 %, 100.3 %, 100.4 %, 100.2 % and 99.9 %, respectively. The detection limits were 0.6, 1, 1, 2.4, 1 and 2.8ng, respectively. |
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| Keywords: | rabeprazole sodium residual organic solvent capillary GC determination |
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