Effect of treatment of rosacea in females by Chibixiao Recipe (赤鼻消方) in combination with minocycline and spironolactone |
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引用本文: | 余土根,郑益志,朱金土,郭雯.Effect of treatment of rosacea in females by Chibixiao Recipe (赤鼻消方) in combination with minocycline and spironolactone[J].Chinese Journal of Integrated Traditional and Western Medicine,2006,12(4):277-280. |
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作者姓名: | 余土根 郑益志 朱金土 郭雯 |
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作者单位: | Department of Dermatology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou (310006) |
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摘 要: | To observe the clinical efficacy of Chibixiao Recipe (赤鼻消方, CBX) in combination with minocycline and spironolactone in treating rosacea in females. Methods: Sixty-eight women with rosacea were randomly assigned to the treated group (48 cases) and the control group (20 cases), both of which were treated with minocycline and spironolactone taken orally, but to the treated group, the Chinese herbal recipe, CBX was given additionally. Besides, cryotherapy with liquid nitrogen was applied to those with apparent capillary dilatation. The therapeutic course for both groups was 8 weeks. The levels of serum testosterone before and after treatment were determined by radioimmunoassay (RIA), and a 4-month followup was conducted. Results: In the treated group the cure-markedly effective rate was 87.5% and the recurrent rate was 6.5 %, while in the control group, they were 45.0 % and 41.2 % respectively. Comparisons in the indexes between the two groups all showed significant difference (both P〈0. 01 ), with the cure-markedly effective rate higher, and the recurrent rate lower in the treated group. The serum level of testosterone got lowered in both groups ( P〈0. 05 and P〈0. 01 ), but the lowering in the treated group was more significant, showing significance when compared with that in the control group ( P〈0. 01 ). Conclusion: CBX in combination with Western medicine has effect in treating rosacea superior to that of Western medicine alone, and could effectively reduce recurrent rate and the serum level of testosterone.
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关 键 词: | 红斑痤疮 二甲胺四环素 螺旋内酯甾酮 赤鼻消方 睾丸激素 |
收稿时间: | 2006-01-08 |
Effect of treatment of rosacea in females by Chibixiao Recipe in combination with minocycline and spironolactone |
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Authors: | Prof Tu-gen Yu Yi-zhi Zheng Jin-tu Zhu and Wen Guo |
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Institution: | (1) Department of Dermatology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, 310006, China |
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Abstract: | Objective To observe the clinical efficacy of Chibixiao Recipe (赤鼻消方, CBX) in combination with minocycline and spironolactone in treating
rosacea in females.
Methods Sixty-eight women with rosacea were randomly assigned to the treated group (48 cases) and the control group (20 cases), both
of which were treated with minocycline and spironolactone taken orally, but to the treated group, the Chinese herbal recipe,
CBX was given additionally. Besides, cryotherapy with liquid nitrogen was applied to those with apparent capillary dilatation.
The therapeutic course for both groups was 8 weeks. The levels of serum testosterone before and after treatment were determined
by radioimmunoassay (RIA), and a 4-month follow-up was conducted.
Results In the treated group the cure-markedly effective rate was 87.5% and the recurrent rate was 6.5%, while in the control group,
they were 45.0% and 41.2% respectively. Comparisons in the indexes between the two groups all showed significant difference
(both P<0.01), with the cure-markedly effective rate higher, and the recurrent rate lower in the treated group. The serum level of
testosterone got lowered in both groups (P<0.05 and P<0.01), but the lowering in the treated group was more significant, showing significance when compared with that in the control
group (P<0.01).
Conclusion CBX in combination with Western medicine has effect in treating rosacea superior to that of Western medicine alone, and could
effectively reduce recurrent rate and the serum level of testosterone. |
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Keywords: | female rosacea testosterone Chibixiao Recipe minocycline spironolactone |
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