物理性质对微晶纤维素可压缩性和成型性的影响

 目的 研究微晶纤维素物理性质与可压缩性和成型性的相关性。方法 选择9种不同型号的微晶纤维素，测定其物理性质如粒径分布、含水量、休止角、松装密度和振实密度等，固定填充深度使用单冲压片机Korsch XP1压片，并采用数学模型heckle方程、塑性常数、累计弹性复原、抗张强度及其变化等进行综合评价。结果 物理性质对粉体成型性和模外的累积弹性复原有影响，但对可压缩性无显著性影响；压强对抗张强度变化影响很大，含水量对粒径的影响会加剧抗张强度在贮存过程的变化。结论 微晶纤维素在压缩过程中呈现了良好的可压缩性，但粒径减小会显著降低其成型性，由于水分子会通过改变粒子内部结构而使粒径的大小发生变化，以及在成型过程中具有润滑和黏合作用，所以降低含水量也会降低其成型性，同时也会使片子的机械强度在贮存过程中稳定性变差。

Effect of Physical Properties of Microcrystalline Cellulose on Its Compressibility and Compactability

OBJECTIVE To study correlation between physical properties and compressibility and compactablility of Microcrystalline cellulose. METHODS After determining the physical properties such as particle size distribution， moisture capacity， angle of repose， bulk density， tapped density， the powder was tableted by the Korsch XP1 at the same filling height， and data derived from heckle model， plasticity constant， cumulative elastic recovery， tensile strength and it′s changes with time were evaluated. RESULTS The physical properties of microcrystalline cellulose had great effect on its compactablility as well as cumulative elastic recovery out of die， but not on compressibility. And pressure applied correlated closely with changes of tensile strength in storage， which was intensified by the influence of water in powder on the particle size. CONCLUSION Microcrystalline cellulose shows excellent compressibility， however， particle size reduction is able to decrease the compactability. Since the water in powder can increase particle size by changing internal structure of particles and plays a prerequisite role in lubrication and adherence， the variation of water content may weaken the compatability of microcrystalline cellulose and worsen the mechanical strength stability of tablets in storage.