稳定性心绞痛患者发生急性冠状动脉综合征前后血浆炎性因子水平的变化及意义

目的观察稳定性心绞痛患者发生急性冠状动脉综合征(ACS)前后血浆白细胞介素(IL)-18、IL-10水平的变化,探讨炎症在ACS发生中的作用及防治的新途径。方法检测211例稳定性心绞痛患者IL-18、IL-10水平变化,随访24个月,根据随访结果将患者分为ACS组(38例)及无ACS组(173例),并进行比较。结果 ACS组患者血浆IL-18水平及IL-18/IL-10比值明显高于无ACS组(P<0.01),血浆IL-10水平明显低于无ACS组(P<0.05);ACS组患者发生ACS后血浆IL-18水平及IL-18/IL-10比值明显高于ACS发生前(P<0.01),发生ACS后血浆IL-10水平明显低于ACS发生前(P<0.05)。结论稳定性心绞痛患者血浆IL-18、IL-10水平与ACS的发生密切相关,提示机体炎症在ACS发生中发挥重要作用,抗炎治疗可能是防治ACS的途径之一。

The changes of plasma IL-18 and IL-10 in stable angina pectoris patients before and after occurrence of acute coronary syndromes

Objective To investigate the changes of plasma IL-18 and IL-10 in stable angina pectoris(SAP) patients before and after occurrence of acute coronary syndrome(ACS),probe the role of inflammation in developing ACS and provide new ideas for prevention of ACS.Methods The plasma IL-18,IL-10 of 211 SAP patients were measured.The patients were divided into 2 groups: developing ACS group(38 patients) and no ACS group(173 patients) according to the results of the 24 months' follow-up.Results Plasma IL-18 level and IL-18/IL-10 ratio in ACS group were higher than those in no ACS group(P<0.01),plasma IL-10 level in the ACS group was lower than that in no ACS group(P < 0.01).In ACS group,plasma IL-18 level and IL-18/IL-10 ratio were higher after developing ACS than before(P<0.05),on the contrary,plasma IL-10 level was lower after developing ACS than before(P<0.05).Conclusions The plasma IL-18 and IL-10 levels in the SAP patients are closely related to the development of ACS,which suggests that inflammation plays an important role in developing ACS,and anti-inflammatory treatment might be a new means for preventing ACS.