新疆维吾尔族女性人乳头瘤病毒感染与宫颈癌相关性的流行病学调查

目的　了解新疆维吾尔族女性人乳头瘤病毒（ＨＰＶ）感染及宫颈癌的发病状况，为新疆宫颈癌预防和筛查提供数据。方法　于２００６年采用整群抽样方法选择新疆于田县有性生活、１６～５９岁维吾尔族女性，按年龄分层入组，依次行宫颈液基细胞学检查和ＨＰＶ检测。意义不明的不典型鳞状细胞（ＡＳＣＵＳ）以上或ＨＰＶ阳性者行阴道镜检查及必要的宫颈活检。结果　新疆维吾尔族妇女高危型、低危型和总体ＨＰＶ感染率分别为７.２５％、１.５９％和８.２７％。ＣＩＮⅡ级以上病变和宫颈癌现患率分别为１.９３％和０.２３％。高危型ＨＰＶ在细胞学ＡＳＣＵＳ、鳞状上皮内低度病变（ＬＳＩＬ）和鳞状上皮内高度病变（ＨＳＩＬ）中的比例分别为１３.４６％、６４.７１％和９０.００％；高危型ＨＰＶ在ＣＩＮⅠ、ＣＩＮⅡ、ＣＩＮⅢ和ＩＣＣ的比例分别为６６.６７％、８３.３３％、１００.００％和１００.００％。ＨＰＶ感染率随宫颈病变级别增加有增高趋势，但在ＣＩＮⅡ级以上病变中无统计学差异。结论　新疆维吾尔族女性ＨＰＶ感染率低于我国汉族女性，但宫颈癌现患率高于我国城市汉族女性，低于一些农村汉族女性。新疆维吾尔族女性ＨＰＶ感染率在不同级别宫颈上皮内瘤变中的分布趋势与中国其他地区相似，但同时具有自身民族特征。

Epidemiological survey of the relationship between HPV and cervical cancer in Xinjiang Uygur women

Objective To understand the prevalence of human papilloma virus（HPV） infection and cervical cancer in Xinjiang Uygur women so as to provide data for prevention and screening of cervical cancer in Xinjiang.Methods The study selected Uygur women in Yutian county in Xinjiang who were 16-59 years old by sex life having cluster sampling in 2006.All of the women accepted liquid-based cytology and HPV DNA test（HC2）.The women with cytology of above ASCUS or positive HPV result accepted colposcopy and necessary cervical biopsy.Results The prevalence of high-risk HPV,low-risk HPV and total HPV were 7.25%,1.59% and 8.27% separately.The prevalence of above CIN Ⅱ and cervical cancer were 1.93% and 0.23% separately.The ratio of high-risk HPV in ASCUS,LSIL and HSIL were 13.46%,64.71% and 90.00% respectively.The ratio of high-risk HPV in CIN Ⅰ,CIN Ⅱ,CIN Ⅲ and ICC were 66.67%,83.33%,100.00% and 100.00% respectively.Conclusion The prevalence of HPV in Xinjiang Uygur women was lower than Han natiorality in China.The prevalence of cervical cancer is higher in Xinjiang Uygur women than Han natiorality in cities,and lower than Han natiorality in some rural areas of China.The prevalence of high-risk HPV of HSIL in Uygur women is similar with Han natiorality in the other areas of China.