| 含多西环素的四联方案补救治疗幽门螺杆菌初次根除失败的临床研究 |
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| 引用本文： | 王震华,熊光苏,杨川华,王勇峰,吴叔明.含多西环素的四联方案补救治疗幽门螺杆菌初次根除失败的临床研究[J].胃肠病学,2011,16(4):211-213. |
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| 作者姓名： | 王震华 熊光苏 杨川华 王勇峰 吴叔明 |
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| 作者单位： | 上海交通大学医学院附属仁济医院消化内科上海市消化疾病研究所,200001 |
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| 摘 要： | 幽门螺杆菌（H．pylori）一线三联疗法的根除失败率日益增高。目的：评价含多西环素的四联方案补救治疗H．pylori初次根除失败的有效性和安全性。方法：共纳入37例日．pyZo打初次根除失败的消化性溃疡、慢性萎缩性胃炎或非溃疡性消化不良患者，予四联方案埃索美拉唑（20rag）＋枸橼酸铋钾（220mg）＋多西环素（100mg）＋阿莫西林（1000mg），2次／dx10d。治疗结束4周后行”^13C-尿素呼气试验（UBT）以评估H．pylori根除情况。结果：4例患者失访，25例患者补救治疗成功，8例失败，补救治疗意向治疗（ITT）分析和符合方案（PP）分析根除率分别为67．6％和75．8％。21例（63．6％）患者发生轻微不良反应。结论：含多西环素的四联方案是一种安全、有效的H．pylori初次根除失败后的补救治疗方案。
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| 关 键 词： | 多西环素 螺杆菌 幽门 药物疗法 治疗 临床研究性 |
Clinical Study of Doxycycline-based Quadruple Regimen as a Rescue Therapy after Failure of Initial Eradication Therapy of Helicobacter pylori |
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| WANG Zhenhua,XIONG Guangsu,YANG Chuanhua,WANG Yongfeng,WU Shuming.Clinical Study of Doxycycline-based Quadruple Regimen as a Rescue Therapy after Failure of Initial Eradication Therapy of Helicobacter pylori[J].Chinese Journal of Gastroenterology,2011,16(4):211-213. |
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| Authors: | WANG Zhenhua XIONG Guangsu YANG Chuanhua WANG Yongfeng WU Shuming |
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| Institution: | WANG Zhenhua,XIONG Guangsu,YANG Chuanhua,WANG Yongfeng,WU Shuming.Department of Gastroenterology,Renji Hospital,Shanghai Jiaotong University School of Medicine Shanghai Institute of Digestive Disease,Shanghai(200001) |
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| Abstract: | Background: The failure rate of first-line triple therapy for Helicobacter pylori(H.pylori) is increasing in recent years.Aims: To assess the efficacy and safety of doxycycline-based quadruple regimen as a rescue therapy after failure of initial eradication therapy of H.pylori.Methods: Thirty-seven patients with peptic ulcer,chronic atrophic gastritis or non-ulcer dyspepsia,who had a failed course of initial eradication therapy,were given the following quadruple therapy: esomeprazole(20 mg)+bismuth potassiu... |
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| Keywords: | Doxycycline Helicobacter pylori Drug Therapy Therapies Investigational |
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