| 地塞米松对刀豆蛋白A引起肝损伤小鼠的保护作用 |
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| 引用本文： | 李小刚 王天才. 地塞米松对刀豆蛋白A引起肝损伤小鼠的保护作用[J]. 基础医学与临床, 1998, 18(3): 45-47 |
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| 作者姓名： | 李小刚 王天才 |
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| 作者单位： | [1]湖北省荆州市第一医院 [2]同济医科大学同济医院肝病研究所 |
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| 摘 要： | 用刀豆蛋白Ａ（ＣｏｎＡ）诱导小鼠建立实验性肝损伤动物模型，观察了该模型血浆丙氨酸转氨酶（ＡＬＴ）、肿瘤坏死因子－α（ＴＮＦ－α）及肝超微结构的变化，证明血浆ＴＮＦ－α与肝损伤密切相关，肝超微结构的改变突出表现为肝细胞凋亡和坏死。
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| 关 键 词： | 地塞米松 刀豆蛋白A TNF 肝损伤 肝脏保护 |
The Protective Effect of Dexamethasone against Hepatic Injury Induced by ConA in Mice |
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| Li Xiaogang Wang Tiancai Li Shaobai Tang Wangxian. The Protective Effect of Dexamethasone against Hepatic Injury Induced by ConA in Mice[J]. Basic Medical Sciences and Clinics, 1998, 18(3): 45-47 |
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| Authors: | Li Xiaogang Wang Tiancai Li Shaobai Tang Wangxian |
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| Affiliation: | Li Xiaogang Wang Tiancai * Li Shaobai * Tang Wangxian * |
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| Abstract: | The mouse model of experimental hepatic injury was made by inducement of concanavalin A (ConA).We observed changes of plasma levels of alanine aminotransferase.as well as tumor necrosis factor a and ultrastructure of liver.The results showed that hepatic injury is related to plasma TNF a and characterized by apoptosis and necrosis of hepatic cells.The effects of dexamethasone on this model were also studied.The results showed that pretreatment of mice with dexamethasone protected them from Con A induced hepatic injury.The production of TNF a was significantly suppressed than that of the model group (P<0 001).Ultrastructural pathologic examination gives no evidence for apoptosis and necrosis.These results indicated that the important mechanism of hepatic protection of dexamethasone was carried out through the inhibition of TNF a production in this model. |
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| Keywords: | Dexamethasone Protection Liver Concanavalin A Tumor necrosis factor |
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