New linear polyamine derivatives in spider venoms. |
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| Authors: | Manuel Tzouros Sergiy Chesnov Stefan Bienz Manfred Hesse Laurent Bigler |
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| Institution: | Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. |
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| Abstract: | Linear free polyamines were characterized in the venom of the spiders Agelenopsis aperta, Hololena curta, and Paracoelotes birulai by RP-HPLC coupled to mass spectrometry. The several linear polyamines found were tetramine, pentamine, and hexamine derivatives. Some of these natural products were identified as N-hydroxylated, guanidylated, or acetylated compounds. In addition, the biosynthetical pathway leading to the formation of acylpolyamines in spider venoms is discussed. |
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| Keywords: | Spider toxins APCI MS/MS Triple quadrupole Gas-phase fragmentation |
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