蛋白酪氨酸磷酸酶PRL-3在乳腺癌中表达及意义

目的探讨乳腺浸润性导管癌及乳腺不典型增生组织中蛋白酪氨酸磷酸酶PRL-3表达情况。方法采用SP法及RT-PCR方法检测60份乳腺癌组织及50份乳腺不典型增生组织标本中PRL-3表达情况,分析PRL-3与乳腺浸润性导管癌临床病理特征的关系。结果在乳腺癌癌变过程中PRL-3表达阳性率呈递增趋势;PRL-3表达与有无淋巴结转移有相关性（P=0.011）;PRL-3在乳腺癌中表达明显高于乳腺不典型增生组织（P〈0.05）。结论乳腺癌组织中PRL-3在蛋白及基因水平呈高表达,一定程度上提示PRL-3与乳腺癌发生密切相关。

Expression and significance of protein tyrosine phosphatase PRL-3 in breast cancer

Objective To study the expression of protein tyrosine phosphatase PRL-3 in breast cancer and in adjacent mammary gland tissue.Methods The expression of PRL-3 was detected in 60 paraffin-embedded specimens of breast cancer and 50 copies of atypical hyperplasia mammary tissue with immunohistochemcal stain and RT-PCR.The relationship between PRL-3 expression and clinicopathological features was analyzed.Results The positive expression rate of PRL-3 protein showed an increasing trend in breast carcinogenesis.The expression of PRL-3 was closely correlated with metastasis of lymphatic metastasis（P=0.011）.The expression rate of PRL-3 was higher in breast cancer than that in the atypical hyperplasia mammary tissue（P0.05）.Conclusion PRL-3 shows a high expression in and protein and gene indicates a close correlation with breast cancer.