肝纤维化指标检测在非酒精性脂肪性肝病中应用价值

目的探讨非酒精性脂肪性肝病各期与血清肝纤维化标志物的关系。方法 126例非酒精性脂肪性肝病患者依据病情分为单纯性脂肪肝组51例,非酒精性脂肪性肝炎组42例,与非酒精性脂肪性肝炎相关肝硬化组33例,不嗜酒的体检健康者64名为对照组,检测4组血清透明质酸、Ⅲ型前胶原氨端肽、Ⅳ型胶原、层黏蛋白水平。结果非酒精性脂肪性肝炎组与非酒精性脂肪性肝炎相关肝硬化组各指标水平较对照组增高（P〈0.01）;单纯性脂肪肝组透明质酸与对照组比较差异有统计学意义（P〈0.05）;非酒精性脂肪性肝炎相关肝硬化组各指标水平高于非酒精性脂肪性肝炎组和单纯性脂肪肝组（P〈0.05）。结论肝纤维化血清学指标有助于了解非酒精性脂肪肝病患者肝纤维化程度。

Value of detection of serum markers of liver fibrosis to non-alcoholic fatty liver disease

Objective To study the relationship between non-alcoholic fatty liver disease phases and the serum markers of liver fibrosis.Methods A total of 126 patients with non-alcoholic fatty liver disease were divided into simple fatty liver group（n=51）,non-alcoholic steatohepatitis（NASH） group（n=42） and NASH-related cirrhosis group（n=33）.And another 64 healthy volunteers not being addicted to alcochol were as controls.The serum markers of liver fibrosis were detected including serum hyaluronic acid,type Ⅲ procollagen ammonia-terminal peptide,collagen type Ⅳ and laminin.Results The serum markers of liver fibrosis were higher in NASH group and NASH-related cirrhosis group than those in control group（P0.01）,and higher in NASH-related cirrhosis group than those in NASH group and simple fatty liver group（P0.05）.There was no significant difference in serum markers of liver fibrosis between simple fatty liver group and control group（P0.05）.Conclusion The serum markers of liver fibrosis in NAFLD is of greater clinical value to understanding liver fibrosis in patients with non-alcoholic fatty liver disease.