儿茶酚抑素对急性心肌梗死患者近期预后的影响

目的评价儿茶酚抑素（catestatin,CST）对急性心肌梗死患者住院期间预后影响。方法 125例急性心肌梗死患者依据CST浓度四分位数间距分为4组,比较4组间临床特征、住院期间恶性事件发生率,多因素Logistic回归分析筛选影响住院恶性事件相关因素。结果 CST水平随年龄、高敏C-反应蛋白、去甲肾上腺素与氨基末端前脑钠肽（aminoverminal portion of pro-brain natriuretic peptide,NT-proBNP）水平升高而升高（P〈0.05）,随左室射血分数的降低而明显升高（P〈0.01）;多因素Logistic回归分析显示,年龄、CST及NT-proBNP是住院期间恶性事件发生的独立危险因素。结论年龄、CST及NT-proBNP是急性心肌梗死患者住院期间恶性事件发生的独立危险因素,CST水平可有效预测急性心肌梗死患者住院期间预后。

Influence of catestatin levels on the short-term prognosis of acute myocardial infarction

Objective To evaluate the influence of catestatin to the short-term prognosis of acute myocardial infarction（AMI）.Methods The total of 125 patients with AMI were divided into 4 groups according to catestatin interquartile ranges.The clinical features and the incidence of malignant events during hospitalization were compared among groups.Multivariate logistic regression analysis was used to determine the correlation factor for malignant events during hospitalization.Results The catestatin level increased with the increase of the age,high sensitivity C-reactive protein,norepinephrine and aminoterminal portion of pro-brain natriuretic peptide（NT-proBNP） levels（P0.05）,and with the decrease of left ventriclular ejection fraction（P0.01）.The multivariate regression analysis showed age,catestatin,NT-proBNP were independent risk factors for malignant events during hospitalization.Conclusion The age,catestatin and NT-proBNP level are independent risk factors for malignant events during hospitalization in patients with AMI.Catestatin level can be used to predict the prognosis of AMI.