正交试验法优选复方白葛胶囊的提取工艺

目的优选复方白葛胶囊的提取工艺。方法采用正交试验法，对水提取工艺和醇沉工艺进行考察。水提工艺以加水量、提取时间、提取次数为考察因素，醇沉工艺以药液浓度、醇沉浓度、静置时间为考察因素，分别以君药中指标性成分芍药苷的转移率作为考察指标进行工艺优选。结果优选的水提工艺为：处方药材用15倍药材量的水煮提2次，每次2h；醇沉工艺为：药液浓缩至含原药材1．0g／mL，加乙醇至醇浓度为70％，放置18h。结论该工艺简便易行，经济实用，提高了生产效率。

Optimization on Extracting Technology of Baige Capsule by Orthogonal Design

Objective To optimize an extracting technology for Fufang Baige capsule. Methods The orthogonal design was used for the inspection of water-extracting process and alcohol-precipitating process. Water volume, extracting time and extracting times were screened as inspection elements for water-extracting process. And liquid concentration, alcohol-precipitating concentration and incubating time were screened as inspection elements for alcohol-precipitating process. The transferring rate of paeoniflorin which is the indicator component in drug-dun was screened as the inspection indicator for each fraction of extraction process. Results The optimal extraction conditions were as follows： for waterextracting process, that was extracting 2 times with 15-fold water, 2 hours for each time; For alcohol-precipitating process, that was concentrating liquid to 1.0 g/mL Chinese herbs containing, then adding alcohol untill alcohol concentration ammouted to 70%, and at last putting it static for 18 hours. Conclusion The extracting technology was simple, economical and practical, and was able to increase production efficiency.