| 环加氧酶与放射性胃肠道损伤 |
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| 引用本文： | 王涛,粟永萍. 环加氧酶与放射性胃肠道损伤[J]. 国际放射医学核医学杂志, 2005, 29(6): 278-281 |
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| 作者姓名： | 王涛 粟永萍 |
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| 作者单位： | 400038 重庆, 第三军医大学预防医学院全军复合伤研究所, 创伤、烧伤与复合伤国家重点实验室 |
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| 摘 要： | 前列腺素是一类重要的类花生酸类化合物,它们具有多种生物功能。环加氧酶(COX)是前列腺素合成的限速酶,存在两个亚型:COX-1和COX-2。研究表明,前列腺素和COX对于胃肠道有积极的保护作用,本文就其在放射性胃肠道损伤中作用的研究进展兼其生物化学和生理作一综述。
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| 关 键 词： | 前列腺素 环加氧酶 放射性胃肠道损伤 |
| 文章编号： | 1001-098X(2005)06-0278-04 |
| 收稿时间： | 2005-03-20 |
| 修稿时间： | 2005-03-20 |
Cyclooxygenase and radiation-induced gastrointestinal injury |
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| WANG Tao,SU Yong-ping. Cyclooxygenase and radiation-induced gastrointestinal injury[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2005, 29(6): 278-281 |
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| Authors: | WANG Tao SU Yong-ping |
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| Affiliation: | State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China |
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| Abstract: | Prostaglandins is a family of eicosanoids, which have many biological functions. Cyclooxygenase is the key enzyme of the prostaglandins' biosynthesis and it has two isoforms: COX1 and COX2. Many researchs indicate that prostaglandins and cyclooxygenase play positive protective role in gastrointestinal tract. In this review, the role of prostaglandins and cyclooxygenase in radiationinduced gastrointestinal injury, as well as their biochemistry and physiology is summarized. |
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| Keywords: | prostaglandins cyclooxygenase radiation-induced gastrointestinal injury |
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