EFFECTIVE INVERSION OF LEFT HEART REMODELING BY PHENYLALANINE IN ESSENTIAL HYPERTENSION

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EFFECTIVE INVERSION OF LEFT HEART REMODELING BY PHENYLALANINE IN ESSENTIAL HYPERTENSION

Objective The aim is to ascertain whether phenylalanine (Phe) can inverse the left heart "remodeling" in patients with essential hypertension. Methods The changes of echocardiographic variables were compared after 3,6 and 9 months of observation between the Phe intervention group (Phe lg/d + amiloride complex 1 tablet/d, 20 cases) and control group (placebo lg/d+amiloride complex 1 tablet/d, 20 cases) with either interventricular septum and (or) post-wall thickness≥12mm, and were carried on further to compare in cross-over trial. Results (1) Phe improved effectively the left heart and systolic dysfunction; while the improvement, also shown in control group due to the concurrent use of diuretic antihypertensive drug-amiloride complex, was much less evident than that in Phe group. (2) The disturbed left heart structure and systolic function were improved prominently while placebo was crossed over to Phe, and the improvement decreased after Phe was crrossed over to placebo. (3) The changes almost attained to its peak level after 6 months and not improved further at 9 months. (4) The differences seen between above 2 groups could not be explained by their diverse drops of blood pressure. Conclusion Phe does exert an independent inverse effect on cardiac "remodeling", which might implicate an important clinical application upon the prevention and control of essential hypertension and its complications.