| 绒毛膜促性腺激素对NK细胞活性的影响 |
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| 引用本文： | 李铉钊,阎燕华.绒毛膜促性腺激素对NK细胞活性的影响[J].标记免疫分析与临床,2001,8(3):147-155. |
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| 作者姓名： | 李铉钊 阎燕华 |
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| 作者单位： | 天津医科大学基础医学院免疫教研室 |
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| 摘 要： | 为探讨绒毛膜促性腺激素 (HCG)对NK细胞活性的影响及其作用的机理 ,将健康人外周血单核细胞(+PBMC组 )及去除单核细胞的 (-PBMC组 )分别与HCG共同孵育后 ,以改良的MTT法检测NK细胞对其靶细胞K5 6 2 的杀伤活性。结果表明 :(1 )一定剂量 (2 5、50、1 0 0IU/mL)的HCG能显著抑制NK细胞的杀伤活性 ,其中以 50IU/mL的HCG作用最明显 ,而较低剂量 (1 2 .5IU/mL)和较高剂量 (2 0 0IU/mL)的HCG则无抑制作用。(2 )HCG对NK细胞的抑制作用通过单核细胞介导
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| 关 键 词： | 绒毛膜促性腺激素 NK细胞 免疫调节 |
| 文章编号： | 1006-1703(2001)03-0147-09 |
| 修稿时间： | 2000年8月7日 |
The Effect of Human Chorionic Gonadotropin on the Activity of NK Cell |
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| LI Hong-zhao,YAN Yan-hua.The Effect of Human Chorionic Gonadotropin on the Activity of NK Cell[J].Labeled Immunoassays and Clinical Medicine,2001,8(3):147-155. |
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| Authors: | LI Hong-zhao YAN Yan-hua |
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| Abstract: | To study the effect of human chorionic gonadotropin(HCG) on the activity of NK cell, HCG was added to the culture of peripheral blood mononuclear cell(PBMC) or PBMC without monocyte derived from healthy people, and the activity of natural killer cell was measured by MTT colormetric assay. The results showed that (1)HCG of 25-100 IU/mL can inhibit the activity of NK cell significantly. The effect of 50 IU/mL is the most obvious, the lower dose (12.5IU/mL) and the higher dose(200IU/mL) of HCG have no suppression; (2)Monocyte plays an important rule in the effect of HCG inhibiting NK cell activity. |
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| Keywords: | HCG NK cell Immunomodulation |
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