| 高圣草酚衍生物的合成及其生物活性的初步研究 |
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| 引用本文： | 吴云辉,杨福秋. 高圣草酚衍生物的合成及其生物活性的初步研究[J]. 中国医药工业杂志, 1988, 0(1) |
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| 作者姓名： | 吴云辉 杨福秋 |
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| 作者单位： | 上海医药工业研究院，上海医药工业研究院 |
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| 摘 要： | 槲寄生水提取液制成的注射液对冠心病引起的心绞痛有较好的疗效。现以其甙元高圣草酚为先导化合物,合成了具有不同酸、碱性侧链的氨基酸和二肽衍生物。初步药理结果表明,在相同剂量下,所有氨基酸和二肽衍生物(8a～f)对 ADP 诱导的兔血小板聚集的抑制作用均比甙元显著增强。其中,赖氨酸(3e(?)和甘氨酰丙氨酸的衍生物(3f)当剂量为0.54 μmol/ml 时,抑制率可达100%,而甙元在此剂量则无效。
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| 关 键 词： | 槲寄生 高圣草酚 衍生物 合成 生物活性 |
SYNTHESIS AND PRELIMINARY BIOLOGICAL SCREENING OF HOMOERIODICTYOL DERIVATIVES |
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| WU Yun-Hui YANG Fu-Qiu. SYNTHESIS AND PRELIMINARY BIOLOGICAL SCREENING OF HOMOERIODICTYOL DERIVATIVES[J]. , 1988, 0(1) |
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| Authors: | WU Yun-Hui YANG Fu-Qiu |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industry |
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| Abstract: | Seven new derivatives of homoeriodictyol,the aglycone of 3'-methoxy-4',5-dihydroxyflavanone-7-O-glucoside,have been synthesized by introducing neutral,acidic and basic amino acids or dipeptide into the 7 positionof the aglycone molecule.Preliminary pharmacological tests indicated thatcompounds 3a-f have a much stronger inhibitory effect against rabbit plateletsaggregation induced by ADP than aglycone itself. |
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| Keywords: | Viscum coloratum homoeriodictyol derivatives synthesis biological activity |
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