效应室丙泊酚浓度恒定后心血管系统的变化

目的：观察靶控输注丙泊酚效应室浓度达稳态后对血流动力学的影响。方法．20例拟于全麻下行择期骨科手术患者，通过靶控输注丙泊酚与瑞芬太尼实施全凭静脉麻醉。在效应室丙泊酚达到恒定浓度后，应用无创胸内植入技术评估其心血管稳定性并使用脑双频谱指数监测麻醉深度。结果：在丙泊酚效应室浓度达稳态后，20min心率达到稳定状态，BIS在32min，心脏指数和平均动脉压在47min达到稳定状态；各指标最终水平较最初稳定状态分别低21％、47％、14％和28％。结论：靶控输注丙泊酚，在效应室浓度达稳态后，心血管指标的变化程度达到了临床有意义的水平。

Changes in the Cardiovascular System after Propofol Effect Compartment Concentration Reaches a Steady State

Objective： To investigate the effect of target-controlled infusions of propofol on hemodynamics of patients. Methods：20 patients scheduled for their elective orthopedic surgery underwent their intravenous anesthesia through target controlled infusions of propofol. The non-invasive thoracic bioimpedance and ＇depth＇ of anaesthesia were used to assess their steady state in the cardiovascular system and the Bispectral index, used to monitor the effect site concentration of the drug after they had been anesthetized to reach a constant effect site concentration of propofol. Results：Their heart rates levelled off at 20 min, Bispectral index, at 32 min, and cardiac index and mean arterial pressure, at 47 rain after achieving its effect site stability with their final levels being 21% ,47 % , 14 % and 28 % , respectively, which were lower than those at their initial effect site stability. Conclusion：The cardiovascular parameters continued to change to a clinically significant degree after achieving a constant effect site concentration of propofol via target-controlled infusions.